Precise detection of G-quadruplexs in living systems: principles, applications, and perspectives
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d5sc00918a
Abstract: G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that play a crucial role in regulating essential cellular processes such as replication, transcription, and translation. The formation of G4s is dynamically controlled by the physiological state… read more here.
Keywords: detection; quadruplexs living; detection quadruplexs; principles applications ... See more keywords
Preprocessing Sequence Coverage Data for More Precise Detection of Copy Number Variations
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2018.2869738
Abstract: Copy number variation (CNV) is a type of genomic/genetic variation that plays an important role in phenotypic diversity, evolution, and disease susceptibility. Next generation sequencing (NGS) technologies have created an opportunity for more accurate detection… read more here.
Keywords: sequence coverage; copy number; detection; precise detection ... See more keywords