Precision medicine‐based therapies in advanced colorectal cancer: The University of California San Diego Molecular Tumor Board experience
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13202
Abstract: Treatment for advanced colorectal cancer is often limited by complex molecular profiles, which promote resistance to systemic agents and targeted monotherapies. Recent studies suggest that a personalized, combinatorial approach of matching drugs to tumor alterations… read more here.
Keywords: advanced colorectal; precision medicine; colorectal cancer; tumor ... See more keywords
Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201700449
Abstract: Abstract Extracellular vesicles (EVs) are ubiquitous nanosized membrane vesicles consisting of a lipid bilayer enclosing proteins and nucleic acids, which are active in intercellular communications. EVs are increasingly seen as a vital component of many… read more here.
Keywords: extracellular vesicles; medicine; precision medicine; personalized precision ... See more keywords
Hope and challenge: Precision medicine in bladder cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1979
Abstract: Bladder cancer (BC) is a complex disease and could be classified into nonmuscle‐invasive BC (NMIBC) or muscle‐invasive BC (MIBC) subtypes according to the distinct genetic background and clinical prognosis. Until now, the golden standard and… read more here.
Keywords: medicine; bladder cancer; precision; precision medicine ... See more keywords
Application of organoid culture from HPV18‐positive small cell carcinoma of the uterine cervix for precision medicine
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5588
Abstract: Small cell carcinoma of the uterine cervix (SCCC) is a rare and highly malignant human papillomavirus (HPV)‐associated cancer in which human genes related to the integration site can serve as a target for precision medicine.… read more here.
Keywords: cell carcinoma; precision medicine; small cell; carcinoma uterine ... See more keywords
Implementation of precision medicine in clinical trials in thoracic oncology: Which are the hurdles?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.31055
Abstract: The adequate histologic subtyping of non–small cell lung cancer (NSCLC) secondary to the clinical need of tailoring systemic therapies has been challenged by small sample sizes of primary or metastatic lung tumors obtained through fineneedle… read more here.
Keywords: medicine; precision medicine; biomarker; disease ... See more keywords
Mapping oncogenic protein interactions for precision medicine
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33954
Abstract: Normal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs,… read more here.
Keywords: precision medicine; protein; protein interactions; medicine ... See more keywords
Molecular prediction of clinical response to anti‐PD‐1/anti‐PD‐L1 immune checkpoint inhibitors: New perspectives for precision medicine and mass spectrometry‐based investigations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34366
Abstract: Monoclonal antibodies (mAbs) acting as immune checkpoint inhibitors (ICIs) are among the most frequently used immunotherapies in oncology. However, precision medicine approaches to adapt the treatment to the patient are still poorly exploited. Given the… read more here.
Keywords: checkpoint inhibitors; immune checkpoint; precision medicine; anti ... See more keywords
Detergents: Friends not foes for high‐performance membrane proteomics toward precision medicine
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600209
Abstract: Precision medicine, particularly therapeutics, emphasizes the atomic‐precise, dynamic, and systems visualization of human membrane proteins and their endogenous modifiers. For years, bottom‐up proteomics has grappled with removing and avoiding detergents, yet faltered at the therapeutic‐pivotal… read more here.
Keywords: medicine; precision medicine; membrane proteomics; toward precision ... See more keywords
Generating Proteomic Big Data for Precision Medicine
Sign Up to like & getrecommendations! Published in 2020 at "PROTEOMICS"
DOI: 10.1002/pmic.201900358
Abstract: Here, the authors reason that the complexity of medical problems and proteome science might be tackled effectively with deep learning (DL) technology. However, deployment of DL for proteomics data requires the acquisition of data sets… read more here.
Keywords: medicine; big data; precision medicine; proteomic big ... See more keywords
Artificial Intelligence and Precision Medicine: A Perspective.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_652
Abstract: This article aims to present how the advanced solutions of artificial intelligence and precision medicine work together to refine medical management. Multi-omics seems the most suitable approach for biological analysis of data on precision medicine… read more here.
Keywords: artificial intelligence; medicine; precision medicine; intelligence precision ... See more keywords
DNA Methylation in Atrial Fibrillation and Its Potential Role in Precision Medicine.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0904-0_11
Abstract: Atrial fibrillation (AF), a common arrhythmia, can cause many serious consequences, including stroke and even death. The pathological mechanism of AF is very complicated. Epigenetic mechanisms, especially DNA methylation, contribute to the pathogenesis and maintenance… read more here.
Keywords: atrial fibrillation; medicine; methylation; precision medicine ... See more keywords