Next‐generation sequencing in precision oncology: Patient understanding and expectations
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1947
Abstract: Implementation of precision oncology interventions poses several challenges to informed consent and patient education. This study assessed cancer patients’ understanding, expectations, and outcomes regarding participation in research examining the impact of matched tumor and germline… read more here.
Keywords: understanding expectations; precision oncology; next generation; oncology ... See more keywords
Molecular predictive testing in precision oncology: The Italian experience
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22290
Abstract: In this review, we describe molecular pathology testing to predict response to targeted treatment of solid tumors, focusing on Italian routine clinical practice. The combination of the universal health care system organized at national, regional,… read more here.
Keywords: molecular predictive; testing precision; pathology; predictive testing ... See more keywords
Precision oncology: East meets West
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31218
Abstract: Introduction Precision oncology aims to customize targeted cancer therapies to the patient’s specific cancer molecular aberration(s). Evaluating a patient’s tumor molecular profile with next generation sequencing and other modern technologies to identify actionable abnormalities for… read more here.
Keywords: medicine; oncology east; precision oncology; cancer ... See more keywords
Precision Oncology for Cancer Immunotherapies in Early-Phase Clinical Trials
Sign Up to like & getrecommendations! Published in 2019 at "Targeted Oncology"
DOI: 10.1007/s11523-019-00678-w
Abstract: The clinical development of cancer drugs is rapidly moving from empirical “one drug fits all” or development-by-tumor-type approaches towards more personalized treatment models. A deeper understanding of cancer and the immune system, novel technologies, and… read more here.
Keywords: early phase; precision oncology; cancer; oncology ... See more keywords
Revolutionizing Precision Oncology through Collaborative Proteogenomics and Data Sharing
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DOI: 10.1016/j.cell.2018.04.008
Abstract: The integration of proteomics into precision oncology presents opportunities that may transform the molecular analysis of cancer and accelerate basic and clinical cancer research. This Commentary discusses the importance of international collaboration and data sharing… read more here.
Keywords: data sharing; precision; oncology collaborative; precision oncology ... See more keywords
Considerations of developing an NGS assay for clinical applications in precision oncology: The NCI-MATCH NGS assay experience.
Sign Up to like & getrecommendations! Published in 2017 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2017.05.003
Abstract: Next generation sequencing (NGS) technologies have been widely adapted in clinical oncology by utilizing the profiled genetic mutation information to select patients and to guide the choice of target therapy. To fulfill the regulatory compliance,… read more here.
Keywords: nci match; ngs assay; precision oncology; oncology ... See more keywords
Precision Oncology for Metastatic Prostate Cancer: Translation into Practice.
Sign Up to like & getrecommendations! Published in 2020 at "European urology"
DOI: 10.1016/j.eururo.2020.08.021
Abstract: While the principles of precision medicine have been readily embraced by all stakeholders, multiple conceptional and structural challenges hinder its broad implementation in clinical practice. PROfound provides the highest level of evidence for the use… read more here.
Keywords: oncology; precision oncology; prostate cancer; practice ... See more keywords
Rate of change in investigational treatment options: An analysis of reports from a large precision oncology decision support effort
Sign Up to like & getrecommendations! Published in 2020 at "International journal of medical informatics"
DOI: 10.1016/j.ijmedinf.2020.104261
Abstract: PURPOSE Genomic analysis of individual patients is now affordable, and therapies targeting specific molecular aberrations are being tested in clinical trials. Genomically-informed therapy is relevant to many clinical domains, but is particularly applicable to cancer… read more here.
Keywords: oncology decision; treatment; treatment options; precision oncology ... See more keywords
Precision Oncology: A Primer for Pediatric Surgeons from the APSA Cancer Committee.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2019.10.017
Abstract: Although most children with cancer can be cured of their disease, a subset of patients with adverse tumor types or biological features, and those with relapsed or refractory disease have significantly worse prognosis. Furthermore, current… read more here.
Keywords: precision oncology; oncology primer; cancer; oncology ... See more keywords
Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications.
Sign Up to like & getrecommendations! Published in 2019 at "New biotechnology"
DOI: 10.1016/j.nbt.2018.09.004
Abstract: Circulating tumour cells (CTCs) originating from a primary tumour, lymph nodes and distant metastases hold great potential for liquid biopsies by providing a molecular fingerprint for disease dissemination and its temporal evolution through the course… read more here.
Keywords: tumour cells; precision oncology; circulating tumour; expression ... See more keywords
Innovative trial design in precision oncology.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2020.09.006
Abstract: Genomic profiling technologies have enabled the development of targeted therapies designed to target specific biomarkers and molecular pathways involved in the pathophysiology of tumor initiation, metastasis, and drug resistance. In recent years, clinical trials with… read more here.
Keywords: trial design; oncology; precision oncology; innovative trial ... See more keywords