Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.08.089
Abstract: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to… read more here.
Keywords: bfl; precision targeting; human cancer; bfl atm ... See more keywords
Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2103532119
Abstract: Significance The targeted killing of cancer cells without affecting surrounding normal cells is the most desirable approach for cancer therapy; however, it cannot be easily achieved, owing to the shared properties of normal and cancer… read more here.
Keywords: cancer; cells using; cancer specific; crispr cas9 ... See more keywords
Transposable elements employ distinct integration strategies with respect to transcriptional landscapes in eukaryotic genomes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa370
Abstract: Abstract Transposable elements (TEs) are ubiquitous DNA segments capable of moving from one site to another within host genomes. The extant distributions of TEs in eukaryotic genomes have been shaped by both bona fide TE… read more here.
Keywords: integration; precision targeting; eukaryotic genomes; elements employ ... See more keywords