Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.08.089
Abstract: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to… read more here.
Keywords: bfl; precision targeting; human cancer; bfl atm ... See more keywords
Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2103532119
Abstract: Significance The targeted killing of cancer cells without affecting surrounding normal cells is the most desirable approach for cancer therapy; however, it cannot be easily achieved, owing to the shared properties of normal and cancer… read more here.
Keywords: cancer; cells using; cancer specific; crispr cas9 ... See more keywords
Transposable elements employ distinct integration strategies with respect to transcriptional landscapes in eukaryotic genomes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa370
Abstract: Abstract Transposable elements (TEs) are ubiquitous DNA segments capable of moving from one site to another within host genomes. The extant distributions of TEs in eukaryotic genomes have been shaped by both bona fide TE… read more here.
Keywords: integration; precision targeting; eukaryotic genomes; elements employ ... See more keywords
Abstract 6569: KLIPP: Precision targeting of cancer with CRISPR
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6569
Abstract: Current cancer therapeutic treatments are typically associated with significant collateral damage to normal tissues and the emergence of treatment resistance. Thus, there is an unmet need to develop therapies that are uniquely cancer specific and… read more here.
Keywords: cancer; cancer specific; klipp precision; precision targeting ... See more keywords
Abstract 4221: Precision targeting of HDAC3 in ovarian cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4221
Abstract: Addressing chemo-resistant homologous recombination-proficient (HRP) ovarian cancers and CCNE1-amplified tumors, while minimizing treatment-related side effects, remains a significant clinical challenge. Our research demonstrated that HDAC inhibition suppresses tumors in PARP inhibitor (PARPi)-resistant ovarian cancers and… read more here.
Keywords: cancer; protac; precision targeting; hdac3 ... See more keywords
Precision Targeting of Mutant PI3Kα.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-23-1392
Abstract: PIK3CA, which encodes the p110α catalytic subunit of PI 3-kinase alpha (PI3Kα), is one of the most frequently genetically activated kinases in solid tumors. In two back-to-back papers, Varkaris and colleagues report on the development… read more here.
Keywords: mutant pi3k; precision targeting; targeting mutant; pi3k ... See more keywords
Precision Targeting of the Gut Microbiome for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-24-0538
Abstract: Transforming gut microbial status from a prognostic trait to a therapeutic target is a key goal to understand and reverse resistance to anticancer immunotherapy. Glitza and colleagues propose selective manipulation of the gut microbiome with… read more here.
Keywords: immunotherapy; precision targeting; gut microbiome; microbiome cancer ... See more keywords