Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500860
Abstract: Closed‐loop control systems have emerged as transformative tools in precision therapy, enabling real‐time monitoring of patient's physiological conditions and automatically adjusting treatments based on direct feedback. By seamlessly integrating sensing feedback and on‐demand therapeutic interventions,… read more here.
Keywords: biomedical devices; multifunctional biomedical; loop systems; precision therapy ... See more keywords
Precision therapy for cancer prevention by targeting carcinogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23798
Abstract: Cancer represents a major global public health burden, with new cases estimated to increase from 14 million in 2012 to 24 million by 2035. Primary prevention is an effective strategy to reduce the costs associated… read more here.
Keywords: cancer; carcinogenesis; prevention; cancer prevention ... See more keywords
CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221365
Abstract: In the last decade, dominant mutations in the mitochondrial protein CHCHD10 (p.R15L and p.S59L) and its paralog CHCHD2 (p.T61I) were shown to cause familial amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), respectively, with phenotypes… read more here.
Keywords: precision therapy; chchd10; chchd10 related; related neurodegeneration ... See more keywords
Progress in precision therapy in pediatric oncology
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000001198
Abstract: Purpose of review The fields of precision medicine and cancer genomics in pediatric oncology are rapidly evolving. Novel diagnostic tools are critical in refining cancer diagnoses, stratifying patient risk, and informing treatment decisions. This review… read more here.
Keywords: precision therapy; oncology; medicine; pediatric oncology ... See more keywords
Perampanel as precision therapy in rare genetic epilepsies
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17530
Abstract: Perampanel, an antiseizure drug with α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist properties, may have a targeted effect in genetic epilepsies with overwhelming glutamate receptor activation. Epilepsies with loss of γ‐aminobutyric acid inhibition (e.g., SCN1A), overactive excitatory neurons… read more here.
Keywords: precision therapy; therapy rare; rare genetic; perampanel precision ... See more keywords
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-21-1566
Abstract: BCL10 mutations in diffuse large B-cell lymphoma (DLBCL) fall into two classes, with both conferring BTK inhibitor resistance but only truncation mutations conferring MALT1 dependency, suggesting use of these mutation classes as precision therapy biomarkers. read more here.
Keywords: precision therapy; mutations define; bcl10 mutations;
CGP-based IO biomarker assessment and treatment utilization across a major US health system.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e23109
Abstract: e23109 Background: Immune checkpoint inhibitors (IO) have become a powerful precision therapy option to treat advanced stage cancer with biomarkers such as PD-L1, tumor mutational burden (TMB), and microsatellite instability (MSI) associated with improved patient… read more here.
Keywords: health system; precision therapy; biomarker; therapy ... See more keywords
Endometrial immune profiling and precision therapy increase live birth rate after embryo transfer: a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1523871
Abstract: Introduction Despite advancements in assisted reproductive treatments, 70% of transferred embryos fail to implant successfully, yielding significant personal and global repercussions. One promising avenue of research is to take into account the individual’s immune uterine… read more here.
Keywords: precision; trial; immune; randomised controlled ... See more keywords
Is Precision Therapy in Infantile-Onset Epileptic Encephalopathies Still Too Far to Call Upon?
Sign Up to like & getrecommendations! Published in 2025 at "Applied Sciences"
DOI: 10.3390/app15052372
Abstract: Epileptic and developmental encephalopathies (EDEs) are a group of severe, genetically various neurological conditions characterized by early-onset seizures and developmental impairments. Recent advances in molecular genetics and diagnostic tools have led to the development of… read more here.
Keywords: infantile onset; therapy; precision; therapy infantile ... See more keywords
Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15092661
Abstract: Simple Summary Triple-negative breast cancer (TNBC), the most aggressive and heterogenous type of cancer, lacks the expression of hormones like estrogen, progesterone, and human epidermal growth receptor-2, making chemotherapy the only treatment regimen against TNBC.… read more here.
Keywords: precision therapy; breast cancer; nanotechnology; tnbc ... See more keywords
Is Vitamin B6 a Precision Therapy for Neonatal Seizures?
Sign Up to like & getrecommendations! Published in 2025 at "Neurology International"
DOI: 10.3390/neurolint17100157
Abstract: Background: Neonatal seizures are critical neurological events with long-term implications for brain development. Standard antiseizure medications, such as phenobarbital, often yield suboptimal seizure control and may be associated with neurotoxicity. This narrative review explores the… read more here.
Keywords: therapy neonatal; seizure; vitamin precision; neonatal seizures ... See more keywords