Multimorbidity Is Associated with Preclinical Alzheimer’s Disease Neuroimaging Biomarkers
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DOI: 10.1159/000489007
Abstract: Background: Identifying comorbidities that influence preclinical Alzheimer’s disease (AD) can give some insight into the AD early stages trajectories to allow new treatment venues and to guide public health systems to prevent subsequent dementia. Objective:… read more here.
Keywords: neuroimaging biomarkers; preclinical alzheimer; alzheimer disease; multimorbidity associated ... See more keywords
Novel Cognitive Paradigms for the Detection of Memory Impairment in Preclinical Alzheimer’s Disease
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DOI: 10.1177/1073191117691608
Abstract: In spite of advances in neuroimaging and other brain biomarkers to assess preclinical Alzheimer’s disease (AD), cognitive assessment has relied on traditional memory paradigms developed well over six decades ago. This has led to a… read more here.
Keywords: paradigms; alzheimer disease; preclinical alzheimer; memory ... See more keywords
The search for meaning in preclinical Alzheimer disease clinical trials
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DOI: 10.1212/wnl.0000000000007817
Abstract: Alzheimer disease (AD) is an age-associated clinical condition marked by neuropathologic β-amyloid plaque and tau accumulation, deterioration in episodic memory and other cognitive abilities, and decline in functional living abilities. According to the newly released… read more here.
Keywords: search meaning; meaning preclinical; alzheimer disease; disease ... See more keywords
Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease
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DOI: 10.1212/wnl.0000000000011477
Abstract: Objective To determine whether memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer disease (AD) biomarkers, we examined associations between performance in 3 memory tasks and CSF β-amyloid (Aβ)42/Aβ40… read more here.
Keywords: alzheimer disease; csf; memory; preclinical alzheimer ... See more keywords
Preclinical Alzheimer Disease and the Electronic Health Record
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DOI: 10.1212/wnl.0000000000201347
Abstract: Because information technologies are increasingly used to improve clinical research and care, personal health information (PHI) has wider dissemination than ever before. The 21st Century Cures Act in the United States now requires patient access… read more here.
Keywords: information; health; alzheimer disease; electronic health ... See more keywords
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected
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DOI: 10.15252/emmm.202012921
Abstract: In Alzheimer’s disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was… read more here.
Keywords: alzheimer continuum; preclinical alzheimer; tau; novel tau ... See more keywords
Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease
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DOI: 10.3389/fnagi.2021.800126
Abstract: Introduction: We investigated whether monthly assessments of a computerized cognitive composite (C3) could aid in the detection of differences in practice effects (PE) in clinically unimpaired (CU) older adults, and whether diminished PE were associated… read more here.
Keywords: alzheimer disease; cognitive testing; computerized cognitive; practice effects ... See more keywords