Advancing Pharmacotherapy Development from Preclinical Animal Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_85
Abstract: Animal models provide rapid, inexpensive assessments of an investigational drug's therapeutic potential. Ideally, they support the plausibility of therapeutic efficacy and provide a rationale for further investigation. Here, I discuss how the absence of clear… read more here.
Keywords: development preclinical; preclinical animal; advancing pharmacotherapy; pharmacotherapy ... See more keywords
Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans.
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DOI: 10.1007/s11095-021-03076-y
Abstract: PURPOSE A dataset of fraction excreted unchanged in the urine (fe) values was developed and used to evaluate the ability of preclinical animal species to predict high urinary excretion, and corresponding poor metabolism, in humans.… read more here.
Keywords: excretion; metabolism humans; preclinical animal; drug ... See more keywords
Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs
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DOI: 10.1128/aac.01639-19
Abstract: For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We… read more here.
Keywords: animal models; preclinical animal; viral reservoirs; penetration ... See more keywords
Reproducibility of preclinical animal research improves with heterogeneity of study samples
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DOI: 10.1371/journal.pbio.2003693
Abstract: Single-laboratory studies conducted under highly standardized conditions are the gold standard in preclinical animal research. Using simulations based on 440 preclinical studies across 13 different interventions in animal models of stroke, myocardial infarction, and breast… read more here.
Keywords: research; animal research; preclinical animal; study ... See more keywords
Reporting quality in preclinical animal experimental research in 2009 and 2018: A nationwide systematic investigation
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DOI: 10.1371/journal.pone.0275962
Abstract: Lack of translation and irreproducibility challenge preclinical animal research. Insufficient reporting methodologies to safeguard study quality is part of the reason. This nationwide study investigates the reporting prevalence of these methodologies and scrutinizes the reported… read more here.
Keywords: preclinical animal; quality; 2009 2018; animal experimental ... See more keywords
Neuropharmacological Effects of Terpenoids on Preclinical Animal Models of Psychiatric Disorders: A Review
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DOI: 10.3390/antiox11091834
Abstract: Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disorders.… read more here.
Keywords: preclinical animal; psychiatric disorders; effects terpenoids; models psychiatric ... See more keywords