IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
Sign Up to like & getrecommendations! Published in 2021 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-021-00893-5
Abstract: Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against… read more here.
Keywords: improving preclinical; cardioprotective interventions; preclinical assessment; cardioprotection ... See more keywords
Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0278-7
Abstract: MP, Ries RE, et al. Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia. Oncotarget. 2016;7:43281–94. 12. Humbert O, Peterson CW, Norgaard ZK, Radtke S, Kiem HP. A nonhuman primate transplantation… read more here.
Keywords: cells preclinical; myeloma; antibody pbd; preclinical assessment ... See more keywords
A preclinical assessment to repurpose drugs to target type 1 diabetes‐associated type B coxsackieviruses
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DOI: 10.1111/dme.14175
Abstract: To screen several antiviral drugs systematically for their efficacy against type B coxsackieviruses. read more here.
Keywords: assessment repurpose; drugs target; repurpose drugs; preclinical assessment ... See more keywords
Development and Validation of [3H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs
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DOI: 10.3390/ph15080960
Abstract: GluN2B-enriched N-methyl-D-aspartate receptors (NMDARs) are implicated in several neurodegenerative and psychiatric diseases, such as Alzheimer’s disease. No clinically valid GluN1/2B therapeutic exists due to a lack of selective GluN2B imaging tools, and the state-of-the-art [3H]ifenprodil… read more here.
Keywords: development validation; ifenprodil; nb1 preclinical; preclinical assessment ... See more keywords