GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.5940
Abstract: Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma‐aminobutyric acid (GABA) is… read more here.
Keywords: anxiety; systematic review; evidence; gaba modulating ... See more keywords
Bimodal Auditory Electrical Stimulation for the Treatment of Tinnitus: Preclinical and Clinical Studies.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2020_180
Abstract: Tinnitus, or the phantom perception of sound, arises from pathological neural activity. Neurophysiological research has shown increased spontaneous firing rates and synchronization along the auditory pathway correlate strongly with behavioral measures of tinnitus. Auditory neurons… read more here.
Keywords: stimulation; treatment; auditory electrical; tinnitus ... See more keywords
Exposure to gadolinium and neurotoxicity: current status of preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2020 at "Neuroradiology"
DOI: 10.1007/s00234-020-02434-8
Abstract: Gadolinium is a rare-earth lanthanide metal that is known to have a direct neurotoxic effect. The scope of the present review is to summarize the current preclinical and clinical evidence on the association between exposure… read more here.
Keywords: preclinical clinical; exposure gadolinium; gadolinium; gadolinium neurotoxicity ... See more keywords
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
Sign Up to like & getrecommendations! Published in 2018 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-018-0696-8
Abstract: Hans Erik Bøtker1 · Derek Hausenloy2,3,4,5,6 · Ioanna Andreadou7 · Salvatore Antonucci8 · Kerstin Boengler9 · Sean M. Davidson2 · Soni Deshwal8 · Yvan Devaux10 · Fabio Di Lisa8 · Moises Di Sante8 · Panagiotis… read more here.
Keywords: clinical studies; guidelines rigor; practical guidelines; rigor reproducibility ... See more keywords
Preclinical and clinical studies on cancer-associated cachexia
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DOI: 10.1007/s11515-018-1484-4
Abstract: BackgroundCancer cachexia is the wasting condition that is often seen in advanced stage cancer patients. This wasting is largely attributable to a systemic and progressive loss of skeletal muscle mass that greatly hinders performance of… read more here.
Keywords: clinical studies; cachexia; condition; cachexia preclinical ... See more keywords
Preclinical and Clinical Proof of Concept for Metabolic Intervention in Diabetic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.218
Abstract: Introduction Hyperactivation of the polyol pathway (PP) contributes to development of diabetic complications such as diabetic cardiomyopathy (DbCM). Aldose reductase (AR), the rate-controlling enzyme in the PP, catalyzes NADPH-dependent reduction of glucose to sorbitol. Under… read more here.
Keywords: mice; concept metabolic; diabetic cardiomyopathy; proof concept ... See more keywords
ATOMOXETINE FOR HOARDING DISORDER: A PRECLINICAL AND CLINICAL INVESTIGATION
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.07.016
Abstract: Purpose of the study Hoarding disorder is a mental disorder that has been newly included in the DSM-5 into the obsessive-compulsive and related disorders chapter. To date only two open studies investigated the pharmacological management… read more here.
Keywords: disorder; treatment; investigation; atomoxetine ... See more keywords
The effect of bioactive glasses on spinal fusion: A cross-disciplinary systematic review and meta-analysis of the preclinical and clinical data
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.04.035
Abstract: Pseudarthrosis following spinal fusion is correlated with poorer patient outcomes and consequently is an area of continued interest within spinal research. Recently, bioactive glasses have been proposed as a means of augmenting fusion rates. Here,… read more here.
Keywords: spinal fusion; bioactive glass; bioactive glasses; fusion ... See more keywords
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Reviews"
DOI: 10.1021/acs.chemrev.2c00398
Abstract: The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the… read more here.
Keywords: preclinical clinical; exogenous compounds; positron emission; endogenous natural ... See more keywords
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-020-0339-2
Abstract: The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied in the past decade, but effective approaches to prevent and treat this disease are limited. Diabetic cardiomyopathy occurs as a result of the dysregulated… read more here.
Keywords: oxidative stress; cardiomyopathy potential; preclinical clinical; diabetic cardiomyopathy ... See more keywords
Epigenetic regulation of radioresistance: insights from preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2158810
Abstract: ABSTRACT Introduction Oftentimes, radiation therapy (RT) is ineffective due to the development of radioresistance (RR). However, studies have shown that targeting epigenetic modifiers to enhance radiosensitivity represents a promising direction of clinical investigation. Areas covered… read more here.
Keywords: targeting epigenetic; preclinical clinical; clinical studies; epigenetic modifiers ... See more keywords