Is preclinical data sharing the new norm?
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.05.003
Abstract: Is preclinical data sharing the new norm? In my experience, it is certainly becoming more commonplace. However, it is not yet standard practice and remains the preserve of special projects. Here, I expound the benefits… read more here.
Keywords: new norm; data sharing; preclinical data; sharing new ... See more keywords
Checkpoint inhibitors in ovarian cancer: A review of preclinical data
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2019.06.003
Abstract: Ovarian cancer is the deadliest gynecologic malignancy, and relapse after initial treatment is frequently fatal. Although ovarian cancer typically has an immunosuppressive tumor microenvironment, a strong intratumoral T cell presence is associated with an improved… read more here.
Keywords: checkpoint inhibitors; use; ovarian cancer; cancer ... See more keywords
Abstract 5566: LYC-55716, a first-in-class RORγ agonist: Rationale and preclinical data to support clinical combinations with established immunotherapies
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5566
Abstract: The retinoic acid-related orphan receptor γt (RORγt) is a nuclear receptor transcription factor that acts as an immune cell master control switch driving the generation and function of Th17 (helper) and Tc17 (cytotoxic) T cells.… read more here.
Keywords: clinical combinations; ror; ror agonist; lyc 55716 ... See more keywords
Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.603409
Abstract: Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind,… read more here.
Keywords: vector; cg01; gene therapy; preclinical data ... See more keywords