The preclinical discovery and development of brivaracetam for the treatment of focal epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1366985
Abstract: ABSTRACT Introduction: Brivaracetam (BRV) is a new AED currently licensed for the adjunctive treatment of adult patients with focal epilepsies. It is a ligand of the ubiquitous synaptic vesicle glycoprotein 2A (SV2A). Areas covered: This… read more here.
Keywords: brivaracetam; preclinical discovery; treatment; brv ... See more keywords
The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2153828
Abstract: ABSTRACT Introduction Molnupiravir (MOV) is a broad-spectrum oral antiviral agent approved for the treatment of COVID-19. The results from in vitro and in vivo studies suggested MOV activity against many RNA viruses such as influenza… read more here.
Keywords: discovery development; preclinical discovery; molnupiravir; treatment ... See more keywords
Preclinical discovery and validation of high-dose androgen drug synergies for the treatment of prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.202
Abstract: 202Background: Recent clinical studies have taken advantage of the dichotomous ability of androgen receptor signaling to elicit growth-suppressive and differentiating effects by giving hyper-physiological levels of testosterone. This approach has demonstrated safety, improved quality of… read more here.
Keywords: high dose; preclinical discovery; treatment; dose androgen ... See more keywords