Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2227-7
Abstract: The successful identification of promising investigational therapies for the treatment of epilepsy can be credited to the use of numerous animal models of seizure and epilepsy for over 80 years. In this time, the maximal electroshock… read more here.
Keywords: epilepsy; validation preclinical; preclinical drug; pharmacoresistant ... See more keywords
Mouse models of nonalcoholic steatohepatitis in preclinical drug development.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.06.007
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in the Western world. NAFLD is a complex spectrum of liver diseases ranging from benign hepatic steatosis to its more… read more here.
Keywords: mouse models; nonalcoholic steatohepatitis; preclinical drug; steatohepatitis preclinical ... See more keywords
Can preclinical drug development help to predict adverse events in clinical trials?
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.08.010
Abstract: The development of novel therapeutics is associated with high rates of attrition, with unexpected adverse events being a major cause of failure. Serious adverse events have led to organ failure, cancer development and deaths that… read more here.
Keywords: drug development; preclinical drug; drug; clinical trials ... See more keywords
Microfluidic Droplet-Assisted Fabrication of Vessel-Supported Tumors for Preclinical Drug Discovery.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c23305
Abstract: High-fidelity in vitro tumor models are important for preclinical drug discovery processes. Currently, the most commonly used model for in vitro drug testing remains the two-dimensional (2D) cell monolayer. However, the natural in vivo tumor… read more here.
Keywords: drug discovery; preclinical drug; tumor; vessel supported ... See more keywords
Maximizing the potential of aggressive mouse tumor models in preclinical drug testing
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-91167-6
Abstract: Atypical teratoid rhabdoid tumor (ATRT) is an aggressive embryonal brain tumor among infants and young children. Two challenges exist for preclinical testing in ATRT. First, genetically quiet, ATRT is a difficult tumor to target molecularly.… read more here.
Keywords: drug testing; preclinical testing; preclinical drug; drug ... See more keywords
Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9040150
Abstract: Developing novel drug formulations and progressing them to the clinical environment relies on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity. However, these current techniques have failed to accurately predict the… read more here.
Keywords: application; preclinical drug; development; physiology ... See more keywords
Experience of an academic institute in importing a novel preclinical drug into India
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_292_17
Abstract: The article throws light on the process of importing a novel preclinical drug into India based on the real-life experience from one of our studies. A novel drug “X” acting through a new mechanism of… read more here.
Keywords: novel preclinical; preclinical drug; drug india; drug ... See more keywords