Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00820
Abstract: The ongoing public health emergency of opioid use disorders (OUD) and overdose in the United States is largely driven by fentanyl and its related analogues and has resulted in over 75 673 deaths in 2021. Immunotherapeutics… read more here.
Keywords: selectivity vaccines; preclinical efficacy; acetylfentanyl; sufentanil acetylfentanyl ... See more keywords
Comparison of preclinical efficacy of immunotherapies against HPV-induced cancers
Sign Up to like & getrecommendations! Published in 2024 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2024.2374287
Abstract: ABSTRACT Introduction Persistent infections with the human papilloma viruses, HPV16 and HPV18, are associated with multiple cancers. Although prophylactic vaccines that induce HPV-neutralizing antibodies are effective against primary infections, they have no effect on HPV-mediated… read more here.
Keywords: hpv induced; efficacy; preclinical efficacy; immunotherapies hpv ... See more keywords
Preclinical efficacy profiles of the sigma‐1 modulator E1R and of fenfluramine in two chronic mouse epilepsy models
Sign Up to like & getrecommendations! Published in 2024 at "Epilepsia"
DOI: 10.1111/epi.18037
Abstract: Given its key homeostatic role affecting mitochondria, ionotropic and metabotropic receptors, and voltage‐gated ion channels, sigma‐1 receptor (Sig1R) represents an interesting target for epilepsy management. Antiseizure effects of the positive allosteric modulator E1R have already… read more here.
Keywords: modulator e1r; profiles sigma; epilepsy; preclinical efficacy ... See more keywords
Abstract A212: Preclinical efficacy of MEK inhibition in a K-Ras driven cholangiocarcinoma preclinical model
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-a212
Abstract: Intrahepatic cholangiocarcinoma (iCCA) is a form of deadly malignancy with limited treatment options. Gain-of-function mutations in KRAS are one of the most frequent mutations, found in ~25% of human CCA patients. MEK inhibitors have been… read more here.
Keywords: krasv12 nicd; mek inhibitors; cca; model ... See more keywords
Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood.2023022480
Abstract: Key Points • JNJ-75276617 shows preclinical activity in KMT2A- or NPM1-altered leukemia, synergizing with gilteritinib, venetoclax, and azacitidine.• Antiproliferative activity in cells harboring menin mutations M327I and T349M is due to a unique binding mode. read more here.
Keywords: menin; preclinical efficacy; npm1 altered; jnj 75276617 ... See more keywords
Preclinical efficacy of ribavirin in SHH and group 3 medulloblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosurgery"
DOI: 10.3171/2020.8.peds20561
Abstract: OBJECTIVE Medulloblastoma, the most common pediatric brain malignancy, has Sonic Hedgehog (SHH) and group 3 (Myc driven) subtypes that are associated with the activity of eukaryotic initiation factor 4E (eIF4E), a critical mediator of translation,… read more here.
Keywords: ribavirin; shh group; cell; preclinical efficacy ... See more keywords
Evaluation of Preclinical Efficacy of Curcumin-Loaded Bicosome Systems in Amelioration of Oral Mucositis
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17020181
Abstract: Background/Objectives: Oral mucositis (OM) is a common and debilitating side effect of cancer therapy, characterized by ulceration or inflammation of the oral mucosa. This study evaluates the preclinical efficacy of curcumin-loaded bicosome systems (cur-BS) in… read more here.
Keywords: efficacy; preclinical efficacy; cur; oral mucositis ... See more keywords