Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00820
Abstract: The ongoing public health emergency of opioid use disorders (OUD) and overdose in the United States is largely driven by fentanyl and its related analogues and has resulted in over 75 673 deaths in 2021. Immunotherapeutics… read more here.
Keywords: selectivity vaccines; preclinical efficacy; acetylfentanyl; sufentanil acetylfentanyl ... See more keywords
Abstract A212: Preclinical efficacy of MEK inhibition in a K-Ras driven cholangiocarcinoma preclinical model
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DOI: 10.1158/1535-7163.targ-17-a212
Abstract: Intrahepatic cholangiocarcinoma (iCCA) is a form of deadly malignancy with limited treatment options. Gain-of-function mutations in KRAS are one of the most frequent mutations, found in ~25% of human CCA patients. MEK inhibitors have been… read more here.
Keywords: krasv12 nicd; mek inhibitors; cca; model ... See more keywords
Preclinical efficacy of ribavirin in SHH and group 3 medulloblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosurgery"
DOI: 10.3171/2020.8.peds20561
Abstract: OBJECTIVE Medulloblastoma, the most common pediatric brain malignancy, has Sonic Hedgehog (SHH) and group 3 (Myc driven) subtypes that are associated with the activity of eukaryotic initiation factor 4E (eIF4E), a critical mediator of translation,… read more here.
Keywords: ribavirin; shh group; cell; preclinical efficacy ... See more keywords