Inhibition of polyglutamine aggregation by SIMILAR huntingtin N‐terminal sequences: Prospective molecules for preclinical evaluation in Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.23021
Abstract: The mutant huntingtin protein (mHtt) fragments with expanded polyglutamine sequence forms microscopically visible aggregates in neurons, a hallmark of Huntington's disease (HD). The aggregation process and aggregates are possible targets of therapeutic intervention in HD.… read more here.
Keywords: huntingtin; aggregation; huntington disease; preclinical evaluation ... See more keywords
Preclinical Evaluation of Azabenzimidazole‐Based PET Radioligands for γ‐8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202300813
Abstract: AMPA glutamate receptors (AMPARs) play a pivotal role in excitatory neurotransmission, particularly in the hippocampus where the TARP γ‐8 subunit is enriched and serves as a target for emerging anti‐epileptic drugs. To enable in vivo visualization… read more here.
Keywords: 18f tarp; preclinical evaluation; tarp; azabenzimidazole based ... See more keywords
Preclinical evaluation and phase 1 study of the PI3Kα/δ inhibitor TQ‐B3525 in Chinese patients with advanced cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cancer"
DOI: 10.1002/cncr.35453
Abstract: Phosphatidylinositol 3‐kinase (PI3K) inhibitors transformed management of various malignancies. This study preclinically characterized TQ‐B3525 (dual PI3Kα/δ inhibitor) and assessed the recommended phase 2 dose (RP2D), safety, efficacy, and pharmacokinetics in relapsed or refractory (R/R) lymphoma… read more here.
Keywords: preclinical evaluation; evaluation phase; pi3k inhibitor; pi3k ... See more keywords
Preparation and preclinical evaluation of 68Ga-iPSMA-BN as a potential heterodimeric radiotracer for PET-imaging of prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-018-6285-3
Abstract: In this research, we report the labeling and preclinical evaluation of the heterodimer 68Ga-iPSMA-BN ligand regarding its ability to target the prostate-specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPr) in prostate cancer tumors.… read more here.
Keywords: 68ga ipsma; preclinical evaluation; pet imaging; prostate cancer ... See more keywords
Preclinical evaluation of an innovative anti-TAM approach based on zoledronate-loaded erythrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-018-0560-2
Abstract: In tumor microenvironment, tumor-associated macrophages (TAMs) are implicated in cancer sustainment, metastasis, and drug resistance, raising a growing interest as targets in cancer therapy. Since the bisphosphonate zoledronate has proven to affect TAMs’ functions, the… read more here.
Keywords: tumor; preclinical evaluation; zoledronate; evaluation innovative ... See more keywords
Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-021-00534-y
Abstract: Cancer nanomedicines (NMs) have emerged as potential anticancer therapeutics with advantages of tumor-targeting drug delivery for improved efficacy against human solid tumors. Despite promising data obtained in preclinical studies, few clinical trials have demonstrated successful… read more here.
Keywords: preclinical evaluation; based microtumor; evaluation; microtumor models ... See more keywords
Preclinical Evaluation of Vaccines to Treat Opioid Use Disorders: How Close are We to a Clinically Viable Therapeutic?
Sign Up to like & getrecommendations! Published in 2020 at "CNS Drugs"
DOI: 10.1007/s40263-020-00722-8
Abstract: The ongoing opioid crisis, now into its second decade, represents a global public health challenge. Moreover, the opioid crisis has manifested despite clinical access to three approved opioid use disorder medications: the full opioid agonist methadone,… read more here.
Keywords: use disorder; preclinical evaluation; opioid use; use ... See more keywords
Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis
Sign Up to like & getrecommendations! Published in 2024 at "Parasitology"
DOI: 10.1017/s0031182024001240
Abstract: Visceral leishmaniasis (VL) is a tropical disease that can be fatal if acute and untreated. Diagnosis is difficult, the treatment is toxic and prophylactic vaccines do not exist. Leishmania parasites express hundreds of proteins and… read more here.
Keywords: visceral leishmaniasis; preclinical evaluation; protein; chimeric protein ... See more keywords
Preclinical Evaluation of HSP90 Noninvasive Imaging in Colorectal Cancer Diagnosis.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c05864
Abstract: Heat shock protein 90 (HSP90) is a powerful molecular chaperone responsible for the stability and integrity of various client proteins, including various transcription factors, kinases, and steroid hormone proteins, among others. Overexpression of HSP90 is… read more here.
Keywords: cancer; preclinical evaluation; evaluation hsp90; hsp90 noninvasive ... See more keywords
SPECT/CT Imaging of 111Ag for the Preclinical Evaluation of Silver-Based Antimicrobial Nanomedicines.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c03609
Abstract: With the growing interest in developing silver-based antimicrobials, there is a need to better understand the behavior of silver within biological systems. To address this, we showed that single-photon emission computed tomography (SPECT) is a… read more here.
Keywords: preclinical evaluation; spect imaging; silver; 111ag preclinical ... See more keywords
Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00313
Abstract: Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical… read more here.
Keywords: preclinical evaluation; evaluation new; receptor; ruthenium mediated ... See more keywords