Inhibition of polyglutamine aggregation by SIMILAR huntingtin N‐terminal sequences: Prospective molecules for preclinical evaluation in Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.23021
Abstract: The mutant huntingtin protein (mHtt) fragments with expanded polyglutamine sequence forms microscopically visible aggregates in neurons, a hallmark of Huntington's disease (HD). The aggregation process and aggregates are possible targets of therapeutic intervention in HD.… read more here.
Keywords: huntingtin; aggregation; huntington disease; preclinical evaluation ... See more keywords
Preparation and preclinical evaluation of 68Ga-iPSMA-BN as a potential heterodimeric radiotracer for PET-imaging of prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-018-6285-3
Abstract: In this research, we report the labeling and preclinical evaluation of the heterodimer 68Ga-iPSMA-BN ligand regarding its ability to target the prostate-specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPr) in prostate cancer tumors.… read more here.
Keywords: 68ga ipsma; preclinical evaluation; pet imaging; prostate cancer ... See more keywords
Preclinical evaluation of an innovative anti-TAM approach based on zoledronate-loaded erythrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-018-0560-2
Abstract: In tumor microenvironment, tumor-associated macrophages (TAMs) are implicated in cancer sustainment, metastasis, and drug resistance, raising a growing interest as targets in cancer therapy. Since the bisphosphonate zoledronate has proven to affect TAMs’ functions, the… read more here.
Keywords: tumor; preclinical evaluation; zoledronate; evaluation innovative ... See more keywords
Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-021-00534-y
Abstract: Cancer nanomedicines (NMs) have emerged as potential anticancer therapeutics with advantages of tumor-targeting drug delivery for improved efficacy against human solid tumors. Despite promising data obtained in preclinical studies, few clinical trials have demonstrated successful… read more here.
Keywords: preclinical evaluation; based microtumor; evaluation; microtumor models ... See more keywords
Preclinical Evaluation of Vaccines to Treat Opioid Use Disorders: How Close are We to a Clinically Viable Therapeutic?
Sign Up to like & getrecommendations! Published in 2020 at "CNS Drugs"
DOI: 10.1007/s40263-020-00722-8
Abstract: The ongoing opioid crisis, now into its second decade, represents a global public health challenge. Moreover, the opioid crisis has manifested despite clinical access to three approved opioid use disorder medications: the full opioid agonist methadone,… read more here.
Keywords: use disorder; preclinical evaluation; opioid use; use ... See more keywords
SPECT/CT Imaging of 111Ag for the Preclinical Evaluation of Silver-Based Antimicrobial Nanomedicines.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c03609
Abstract: With the growing interest in developing silver-based antimicrobials, there is a need to better understand the behavior of silver within biological systems. To address this, we showed that single-photon emission computed tomography (SPECT) is a… read more here.
Keywords: preclinical evaluation; spect imaging; silver; 111ag preclinical ... See more keywords
Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00313
Abstract: Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical… read more here.
Keywords: preclinical evaluation; evaluation new; receptor; ruthenium mediated ... See more keywords
Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
Sign Up to like & getrecommendations! Published in 2021 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00213
Abstract: The lengthy treatment time for tuberculosis (TB) is a primary cause for the emergence of multidrug resistant tuberculosis (MDR-TB). One approach to improve TB therapy is to develop an inhalational TB therapy that when administered… read more here.
Keywords: preclinical evaluation; spectinamide 1599; tuberculosis; therapy ... See more keywords
Preclinical Evaluation of Novel PET Probes for Dementia.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2023.03.004
Abstract: The development of novel PET imaging agents that selectively bind specific dementia-related targets can contribute significantly to accurate, differential and early diagnosis of dementia causing diseases and support the development of therapeutic agents. Consequently, in… read more here.
Keywords: evaluation; preclinical evaluation; pet probes; pet ... See more keywords
Preclinical Evaluation of Chimeric Antigen Receptor-Modified T Cells Specific to Epithelial Cell Adhesion Molecule for Treating Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Human gene therapy"
DOI: 10.1089/hum.2019.178
Abstract: This is an erratum of the published paper "Preclinical Evaluation of Chimeric Antigen Receptor-Modified T Cells Specific to Epithelial Cell Adhesion Molecule for Treating Colorectal Cancer". There are some errors in figure 6C and 7C… read more here.
Keywords: preclinical evaluation; modified cells; receptor modified; antigen receptor ... See more keywords
Preclinical evaluation of semi‐automated laser ablation for pulmonary vein isolation: A comparative study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Electrophysiology"
DOI: 10.1111/jce.15777
Abstract: Visually‐guided laser balloon ablation (VGLA) currently requires careful manual rotation of the laser to create overlapping lesions. A novel semi‐automated VGLA may reduce ablation times and lesion gaps. We aimed to compare semi‐automated (SA) VGLA… read more here.
Keywords: preclinical evaluation; ablation; evaluation semi; semi automated ... See more keywords