Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases
Sign Up to like & getrecommendations! Published in 2024 at "Medicinal Research Reviews"
DOI: 10.1002/med.22014
Abstract: Adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) is a highly conserved eukaryotic enzyme discovered as a key regulator of cellular energy homeostasis, with anti‐inflammation, antioxidative stress, anticancer, and antifibrosis beneficial effects. AMPK is dysregulated in human… read more here.
Keywords: pulmonary diseases; synthetic compounds; evidence using; using synthetic ... See more keywords
A meta-analysis of animal studies evaluating the effect of hydrogen sulfide on ischemic stroke: is the preclinical evidence sufficient to move forward?
Sign Up to like & getrecommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-024-03291-5
Abstract: Hydrogen sulfide (H2S) is a gasotransmitter that has been studied for its potential therapeutic effects, including its role in the pathophysiology and treatment of stroke. This systematic review and meta-analysis aimed to determine the sufficiency… read more here.
Keywords: meta analysis; ischemic stroke; effect; hydrogen sulfide ... See more keywords
Targeting the PD-1/PD-L1 pathway in glioblastoma multiforme: Preclinical evidence and clinical interventions.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107403
Abstract: Glioblastoma multiforme (GBM), as one of the immunosuppressive and common intrinsic brain tumors in adults, remains an intractable malignancy to manage. Since the standard of care for treatment, which includes surgery and chemoradiation, has not… read more here.
Keywords: multiforme preclinical; glioblastoma multiforme; preclinical evidence; targeting pathway ... See more keywords
Could combination chemotherapy be more effective than monotherapy in the treatment of visceral leishmaniasis? A systematic review of preclinical evidence
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022000142
Abstract: Abstract Abstract From a systematic review framework, we assessed the preclinical evidence on the effectiveness of drug combinations for visceral leishmaniasis (VL) treatment. Research protocol was based on the PRISMA guideline. Research records were identified… read more here.
Keywords: visceral leishmaniasis; treatment; preclinical evidence; systematic review ... See more keywords
Polyvalent immunoglobulin therapy: preclinical evidence and potential for treating chemotherapy-induced peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2025 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2025.2522075
Abstract: ABSTRACT Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and often debilitating complication of cancer treatment, affecting over 68% of treated patients. This condition is characterized by sensory deficits, neuropathic pain, and reduced quality of… read more here.
Keywords: induced peripheral; chemotherapy induced; peripheral neuropathy; preclinical evidence ... See more keywords
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2160703
Abstract: ABSTRACT Introduction Glioblastoma Multiforme (GBM) is one of the fatal cancers of the Central Nervous System (CNS). A variety of reasons exist for why previous immunotherapy strategies, especially Immune Checkpoint Blockers (ICBs), did not work… read more here.
Keywords: ctla; preclinical evidence; glioblastoma preclinical; ctla axes ... See more keywords
Antitumor effects of the multi-target tyrosine kinase inhibitor cabozantinib: a comprehensive review of the preclinical evidence
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2021.1919090
Abstract: ABSTRACT Introduction Altered receptor tyrosine kinase (RTK) signaling contributes to tumorigenesis and suppression of immune-mediated destruction of cancer cells. Cabozantinib is an oral tyrosine kinase inhibitor that inhibits several RTKs involved in tumorigenesis, and is… read more here.
Keywords: cancer; kinase inhibitor; preclinical evidence; tyrosine kinase ... See more keywords
Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvaa239
Abstract: Abstract Aims Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction… read more here.
Keywords: arrhythmia; tbx5; control; preclinical evidence ... See more keywords
β‐Adrenoceptors as drug targets in melanoma: novel preclinical evidence for a role of β3‐adrenoceptors
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14552
Abstract: Stress plays a role in tumourigenesis through catecholamines acting at β‐adrenoceptors including β1‐, β2‐ and β3‐adrenoceptors, and the use of β‐adrenoceptor antagonists seems to counteract tumour growth and progression. Preclinical evidence and meta‐analysis data demonstrate… read more here.
Keywords: drug targets; adrenoceptors drug; evidence; preclinical evidence ... See more keywords
Preclinical Evidence-based Review on Therapeutic Potential of Eugenol for the Treatment of Brain Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220525145521
Abstract: The increasing morbidness of brain disorders and conditions such as anxiety, stress, depression, Alzheimer's disease, Parkinson's disease, and others have become severe. Although researchers have spent a significant amount of time examining these diseases and… read more here.
Keywords: preclinical evidence; based review; brain; evidence based ... See more keywords
Herbal medicines for SOD1G93A mice of amyotrophic lateral sclerosis: preclinical evidence and possible immunologic mechanism
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1433929
Abstract: Currently, there is no cure or effective treatment for Amyotrophic Lateral Sclerosis (ALS). The mechanisms underlying ALS remain unclear, with immunological factors potentially playing a significant role. Adhering to the Preferred Reporting Items for Systematic… read more here.
Keywords: review; amyotrophic lateral; evidence; lateral sclerosis ... See more keywords