Targeting the PD-1/PD-L1 pathway in glioblastoma multiforme: Preclinical evidence and clinical interventions.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107403
Abstract: Glioblastoma multiforme (GBM), as one of the immunosuppressive and common intrinsic brain tumors in adults, remains an intractable malignancy to manage. Since the standard of care for treatment, which includes surgery and chemoradiation, has not… read more here.
Keywords: multiforme preclinical; glioblastoma multiforme; preclinical evidence; targeting pathway ... See more keywords
Could combination chemotherapy be more effective than monotherapy in the treatment of visceral leishmaniasis? A systematic review of preclinical evidence
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022000142
Abstract: Abstract Abstract From a systematic review framework, we assessed the preclinical evidence on the effectiveness of drug combinations for visceral leishmaniasis (VL) treatment. Research protocol was based on the PRISMA guideline. Research records were identified… read more here.
Keywords: visceral leishmaniasis; treatment; preclinical evidence; systematic review ... See more keywords
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2160703
Abstract: ABSTRACT Introduction Glioblastoma Multiforme (GBM) is one of the fatal cancers of the Central Nervous System (CNS). A variety of reasons exist for why previous immunotherapy strategies, especially Immune Checkpoint Blockers (ICBs), did not work… read more here.
Keywords: ctla; preclinical evidence; glioblastoma preclinical; ctla axes ... See more keywords
Antitumor effects of the multi-target tyrosine kinase inhibitor cabozantinib: a comprehensive review of the preclinical evidence
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2021.1919090
Abstract: ABSTRACT Introduction Altered receptor tyrosine kinase (RTK) signaling contributes to tumorigenesis and suppression of immune-mediated destruction of cancer cells. Cabozantinib is an oral tyrosine kinase inhibitor that inhibits several RTKs involved in tumorigenesis, and is… read more here.
Keywords: cancer; kinase inhibitor; preclinical evidence; tyrosine kinase ... See more keywords
Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvaa239
Abstract: Abstract Aims Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction… read more here.
Keywords: arrhythmia; tbx5; control; preclinical evidence ... See more keywords
β‐Adrenoceptors as drug targets in melanoma: novel preclinical evidence for a role of β3‐adrenoceptors
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14552
Abstract: Stress plays a role in tumourigenesis through catecholamines acting at β‐adrenoceptors including β1‐, β2‐ and β3‐adrenoceptors, and the use of β‐adrenoceptor antagonists seems to counteract tumour growth and progression. Preclinical evidence and meta‐analysis data demonstrate… read more here.
Keywords: drug targets; adrenoceptors drug; evidence; preclinical evidence ... See more keywords
Preclinical Evidence-based Review on Therapeutic Potential of Eugenol for the Treatment of Brain Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220525145521
Abstract: The increasing morbidness of brain disorders and conditions such as anxiety, stress, depression, Alzheimer's disease, Parkinson's disease, and others have become severe. Although researchers have spent a significant amount of time examining these diseases and… read more here.
Keywords: preclinical evidence; based review; brain; evidence based ... See more keywords
Shexiang Baoxin Pills for Coronary Heart Disease in Animal Models: Preclinical Evidence and Promoting Angiogenesis Mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00404
Abstract: Shexiang Baoxin Pill (SBP) originated from a classical TCM Fufang Suhexiang Pill for chest pain with dyspnea in the Southern Song Dynasty (1107–110 AD). Here, we aimed to evaluate preclinical evidence and possible mechanism of… read more here.
Keywords: promoting angiogenesis; heart disease; preclinical evidence; coronary heart ... See more keywords
Effect of tanshinone IIA for myocardial ischemia/reperfusion injury in animal model: preclinical evidence and possible mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1165212
Abstract: Introduction: Tanshinone IIA (Tan IIA), the major active lipophilic ingredient of Radix Salviae Miltiorrhizae, exerts various therapeutic effects on the cardiovascular system. We aimed to identify the preclinical evidence and possible mechanisms of Tan IIA… read more here.
Keywords: preclinical evidence; myocardial ischemia; tan iia; iia ... See more keywords
Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076829
Abstract: Background: Adrenocortical cancer (ACC) is a rare malignancy with a dismal prognosis. The treatment includes mitotane and EDP chemotherapy (etoposide, doxorubicin, and cisplatin). However, new therapeutic approaches for advanced ACC are needed, particularly targeting the… read more here.
Keywords: cell; preclinical evidence; cell lines; progesterone ... See more keywords
Predictive Value of MUC5AC Signature in Pancreatic Ductal Adenocarcinoma: A Hypothesis Based on Preclinical Evidence
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098087
Abstract: Mucin 5AC (MUC5AC) glycoprotein plays a crucial role in carcinogenesis and drug sensitivity in pancreatic ductal adenocarcinoma (PDAC), both individually and in combination with other mucins. Its function and localization are glycoform-specific. The immature isoform… read more here.
Keywords: preclinical evidence; muc5ac; ductal adenocarcinoma; evidence ... See more keywords