Nicorandil Repurposing in Orofacial Pain: Preclinical Findings in Adult Zebrafish
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DOI: 10.1002/cmdc.202401007
Abstract: This study investigates the orofacial antinociceptive activity of nicorandil in adult zebrafish and explores the involvement of TRP channels in this effect. Nicorandil, a known antianginal drug, reduces nociceptive behaviors induced by capsaicin (TRPV1 agonist),… read more here.
Keywords: repurposing orofacial; preclinical findings; adult zebrafish; nicorandil repurposing ... See more keywords
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.971687
Abstract: The variant virus-based 2019 coronavirus disease (COVID-19) pandemic has reportedly impacted almost all populations globally, characterized by a huge number of infected individuals. Clinical evidence proves that patients with cancer are more easily infected with… read more here.
Keywords: pharmacology; targeting autophagy; covid; pharmacological targets ... See more keywords
The Rocky Road from Preclinical Findings to Successful Targeted Therapy in Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113422
Abstract: Pleural mesothelioma (PM) is a rare and aggressive disease that arises from the mesothelial cells lining the pleural cavity. Approximately 80% of PM patients have a history of asbestos exposure. The long latency period of… read more here.
Keywords: rocky road; pleural mesothelioma; road preclinical; findings successful ... See more keywords