Immune profiling of melanoma tumors reflecting aggressiveness in a preclinical model
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2056-1
Abstract: Melanoma, like most solid tumors, is highly heterogeneous in terms of invasive, proliferative, and tumor-initiating potential. This heterogeneity is the outcome of differential gene expression resulting from conditions in the tumor microenvironment and the selective… read more here.
Keywords: melanoma; melanoma tumors; profiling melanoma; preclinical model ... See more keywords
Tannic acid elicits selective antitumoral activity in vitro and inhibits cancer cell growth in a preclinical model of glioblastoma multiforme
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00519-9
Abstract: Glioblastoma is a devastating tumor affecting the central nervous system with infiltrative capacity, high proliferation rate and chemoresistance. Therefore, it is urgent to find new therapeutic alternatives that improve this prognosis. Herein, we focused on… read more here.
Keywords: tannic acid; glioblastoma; preclinical model; cell ... See more keywords
Preclinical model of multiple sclerosis: Methods in autoimmune demyelination.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2021.12.009
Abstract: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that is characterized by progressive demyelination and neurodegeneration. It is considered an autoimmune disorder as autologous myelin-reactive T cells infiltrate the… read more here.
Keywords: preclinical model; model; demyelination; multiple sclerosis ... See more keywords
Zebrafish as a preclinical model for Extracellular Vesicle-based therapeutic development.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.05.025
Abstract: Extracellular Vesicles (EVs) are released during various pathophysiological processes and reflect the state of their cell of origin. Once released, they can propagate through biological fluids, target cells, deliver their content and elicit functional responses.… read more here.
Keywords: extracellular vesicle; zebrafish preclinical; model extracellular; model ... See more keywords
A novel preclinical model of environment-like combined benzene, toluene, ethylbenzene, and xylenes (BTEX) exposure: Behavioral and neurochemical findings.
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2022.107076
Abstract: Environmental exposure to toxicants is a major health issue and a leading risk factor for premature mortality worldwide, including environmental exposures to volatile organic compounds (VOCs), specifically Benzene, Toluene, Ethylbenzene, and Xylene (BTEX). While exposure… read more here.
Keywords: toluene ethylbenzene; preclinical model; exposure; btex exposure ... See more keywords
Validation of schizophrenia gene expression profile in a preclinical model of maternal infection during pregnancy
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.02.005
Abstract: This study was funded by NIH R01 MH084894 and R01 MH111940 grants and SAF2010-20840-C02-01/02 and SAF2013-46292-R from MINECO (Spain read more here.
Keywords: expression profile; gene expression; profile preclinical; schizophrenia gene ... See more keywords
Preclinical Model to Evaluate Outcomes of Amyloid Cross-Toxicity in the Rodent Brain.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00419
Abstract: The progress of neurodegenerative disorders correlates with the spread of their associated amyloidogenic proteins. Here, we investigated whether amyloid entry into nonconstitutive neurons could drive cross-toxic outcomes. Amyloid β (Aβ) was stereotaxically introduced into the… read more here.
Keywords: model evaluate; preclinical model; rodent; cross ... See more keywords
Zebrafish as an Experimental and Preclinical Model for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00583
Abstract: The success rate of novel drug candidates in clinical trials relies on the safety and efficacy data of the preclinical studies. Although cell-based assays are widely used, the complexity of an in vivo system to… read more here.
Keywords: drug discovery; zebrafish experimental; preclinical model; disease ... See more keywords
Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical science"
DOI: 10.1042/cs20220726
Abstract: The placenta represents a non-neuronal organ capable of transporting and metabolizing monoamines. Since these bioactive molecules participate in numerous processes essential for placental and fetal physiology, any imbalance in their levels during pregnancy may affect… read more here.
Keywords: dopamine norepinephrine; preclinical model; dopamine; transport ... See more keywords
Prebiotics improve osteoporosis indicators in a preclinical model: systematic review with meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition reviews"
DOI: 10.1093/nutrit/nuac097
Abstract: CONTEXT Studies using experimental models have demonstrated that prebiotics are involved in antiosteoporotic mechanisms. OBJECTIVE This study was conducted to determine the impact of supplementation with prebiotics in the basal diet of ovariectomized rats with… read more here.
Keywords: preclinical model; prebiotics improve; review; bone ... See more keywords
A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Radiation Research"
DOI: 10.1101/2022.05.19.492439
Abstract: Radiotherapy of head and neck cancer is known to cause both early and late-occurring toxicities. To better appraise normal tissue responses and their dependence on treatment parameters such as radiation field and type, as well… read more here.
Keywords: preclinical model; normal tissue; head neck; tissue ... See more keywords