DEVELOPMENT OF NOVEL PRECLINICAL MODELS OF SECONDARY RESISTANCE TO THE PI3KΔ INHIBITOR IDELALISIB IN SPLENIC MARGINAL ZONE LYMPHOMA (SMZL)
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_119
Abstract: rubicin, epirubicin, vinblastine, etoposide, paclitaxel, and topotecan. RTI‐79's PK characteristics are similar to rifabutin and exhibited no overt toxicity in mice at high doses. RTI‐79 did not exacerbate the known cardiotoxicity associated with doxorubicin as… read more here.
Keywords: rti; novel preclinical; secondary resistance; preclinical models ... See more keywords
Deconstructing Schizophrenia: Advances in Preclinical Models for Biomarker Identification.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2018_48
Abstract: Schizophrenia is considered to develop as a consequence of genetic and environmental factors impacting on brain neural systems and circuits during vulnerable neurodevelopmental periods, thereby resulting in symptoms in early adulthood. Understanding of the impact… read more here.
Keywords: schizophrenia; advances preclinical; deconstructing schizophrenia; models biomarker ... See more keywords
Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Heart Failure Reviews"
DOI: 10.1007/s10741-017-9653-0
Abstract: Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection… read more here.
Keywords: dox induced; induced cardiotoxicity; micrornas doxorubicin; cardiotoxicity ... See more keywords
Osteosarcoma in the Post Genome Era: Preclinical Models and Approaches to Identify Tractable Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2019 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-019-00534-w
Abstract: Purpose of ReviewOsteosarcoma (OS) is the most common cancer of bone, yet is classified as a rare cancer. Treatment and outcomes for OS have not substantively changed in several decades. While the decoding of the… read more here.
Keywords: era preclinical; therapeutic targets; genome era; preclinical models ... See more keywords
Non-invasive fluorescence imaging for tracking immune cells in preclinical models of immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2021.06.016
Abstract: The field of cellular immunotherapy for cancer has experienced exponential growth over the last decade. Several chimeric antigen receptor T cell products have already received FDA approval, which has stimulated growth and enthusiasm for other… read more here.
Keywords: immune cells; tracking immune; fluorescence imaging; non invasive ... See more keywords
Preclinical models and neurocircuitry of gambling and impulsive behavior
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2016.11.009
Abstract: Impulsivity is thought to contribute to the development and maintenance of gambling disorder, but the mechanistic relationship between these complex and multifaceted behaviors is unclear. Animal models have been developed to examine various aspects of… read more here.
Keywords: models neurocircuitry; neurocircuitry gambling; gambling impulsive; preclinical models ... See more keywords
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.04.009
Abstract: Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been… read more here.
Keywords: liver ampk; cholesterol; lipid cholesterol; ampk 06409577 ... See more keywords
Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.033
Abstract: Phosphatidylinositide 3-kinases (PI3Ks) are widely expressed enzymes involved in membrane signalization pathways. Attempts to administer inhibitors with broad activity against different isoforms have failed due to toxicity. Conversely the PI3Kδ isoform is much more selectively… read more here.
Keywords: anti pi3k; compound; preclinical models; atopic ... See more keywords
Preclinical Models for Bladder Cancer Research.
Sign Up to like & getrecommendations! Published in 2021 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2021.02.007
Abstract: At diagnosis, more than 70% of bladder cancers (BCs) are at the non-muscle-invasive bladder cancer (NMIBC) stages, which are usually treated with transurethral resection followed by intravesical instillation. For the remaining advanced cancers, systemic therapy… read more here.
Keywords: bladder cancer; cancer research; preclinical models; cancer ... See more keywords
Preclinical models of non-alcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.10.031
Abstract: Non-alcoholic fatty liver disease (NAFLD) can manifest as non-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH). NASH is often associated with progressive fibrosis which can lead to cirrhosis and hepatocellular carcinoma (HCC). NASH is increasing… read more here.
Keywords: alcoholic fatty; fatty liver; non alcoholic; disease ... See more keywords
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04356-9
Abstract: T- and NK-cell lymphomas (TCL) are a heterogenous group of lymphoid malignancies with poor prognosis. In contrast to B-cell and myeloid malignancies, there are few preclinical models of TCLs, which has hampered the development of… read more here.
Keywords: vulnerabilities cell; identified preclinical; cell lymphomas; preclinical models ... See more keywords