Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL
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DOI: 10.1158/1535-7163.mct-17-1123
Abstract: MLL-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis. Despite the development of specific therapeutic protocols, infant patients with MLL-rearranged ALL still suffer… read more here.
Keywords: mll af4; model mll; mouse model; mll rearranged ... See more keywords
Circulating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis
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DOI: 10.3390/diagnostics8020030
Abstract: The majority of cancer deaths occur because of metastasis since current therapies are largely non-curative in the metastatic setting. The use of in vivo preclinical mouse models for assessing metastasis is, therefore, critical for developing… read more here.
Keywords: mouse models; metastasis; circulating tumor; biology ... See more keywords