Preclinical pharmacokinetic profiling of IQG‐607, a potential oral metallodrug to treat tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.10.020
Abstract: ABSTRACT IQG‐607 is an analog of isoniazid with anti‐tuberculosis activity. This work describes the development and validation of an HPLC method to quantify pentacyano(isoniazid)ferrate(II) compound (IQG‐607) and the pharmacokinetic studies of this compound in mice.… read more here.
Keywords: pharmacokinetic profiling; treat; preclinical pharmacokinetic; iqg ... See more keywords
Preclinical pharmacokinetic study of a novel lipid-lowering agent, IMM-H007.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202011_23544
Abstract: The article "Preclinical pharmacokinetic study of a novel lipid-lowering agent, IMM-H007, by Z.-L. Zhang, W.-Q. Liu, X.-Z. Deng, published in Eur Rev Med Pharmacol Sci 2018; 22 (24): 8939-8950-DOI: 10.26355/eurrev_201812_16664-PMID: 30575938" has been withdrawn from… read more here.
Keywords: study novel; imm h007; preclinical pharmacokinetic; imm ... See more keywords
In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-180165
Abstract: Diffusible amyloid-β (Aβ) oligomers are currently presumed to be the most cytotoxic Aβ assembly and held responsible to trigger the pathogenesis of Alzheimer’s disease (AD). Thus, Aβ oligomers are a prominent target in AD drug… read more here.
Keywords: disease vitro; preclinical pharmacokinetic; alzheimer disease; disease ... See more keywords
Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters
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DOI: 10.3390/molecules27082451
Abstract: Urea transporter (UT) inhibitors are a class of promising novel diuretics that do not cause the imbalance of Na+, K+, Cl−, and other electrolytes. In our previous studies, 25a, a promising diuretic candidate inhibiting UT,… read more here.
Keywords: novel diuretic; inhibiting; pharmacokinetic studies; preclinical pharmacokinetic ... See more keywords
Development and Validation of an LC-MS/MS Method for Quantification of the Novel Antibacterial Candidate DA-7010 in Plasma and Application to a Preclinical Pharmacokinetic Study
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DOI: 10.3390/ph14020163
Abstract: DA-7010 is a new candidate for an antibacterial agent that targets Gram-negative pathogens by acting as a leucyl-tRNA synthetase inhibitor. In this study, a simple and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was… read more here.
Keywords: plasma; preclinical pharmacokinetic; candidate; study ... See more keywords