Abstract 2419: A multimodel preclinical platform to evaluate photodynamic therapy as a strategy to reduce local recurrence in myxofibrosarcoma and osteosarcoma
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DOI: 10.1158/1538-7445.am2023-2419
Abstract: Sarcomas are heterogeneous and rare malignant tumors that develop from connective tissues. Myxofibrosarcoma (MFS) and Osteosarcoma (OS) are the main representative subtypes of Soft tissues and Bone sarcomas. Conventional treatment consists of surgical resection and… read more here.
Keywords: cell; local recurrence; preclinical platform; strategy ... See more keywords
Abstract 4664: MatchR a preclinical platform of models resistant to innovative therapies
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DOI: 10.1158/1538-7445.am2023-4664
Abstract: Introduction: In the last 20 years, the advances in molecular oncology and cancer genetics allowed the identification of an increasing number of actionable oncogenic drivers and the development and clinical use of specific inhibitors. Despite… read more here.
Keywords: preclinical platform; resistance; patient derived; post ... See more keywords
Abstract 4677: A preclinical platform of breast cancer PDX and derived cellular models as a tool for pharmacological screening and functional studies
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DOI: 10.1158/1538-7445.am2023-4677
Abstract: Despite considerable progress in understanding the biology and genetics of breast cancer, the development of effective therapies needs physiological and predictive preclinical models. In this context, breast cancer (BC) patient-derived xenograft (PDX) models have become… read more here.
Keywords: pdx; biology; preclinical platform; breast cancer ... See more keywords
Preclinical Platform Using a Triple-negative Breast Cancer Syngeneic Murine Model to Evaluate Immune Checkpoint Inhibitors
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DOI: 10.21873/anticanres.16137
Abstract: Background/Aim: To evaluate the feasibility of syngeneic mouse models of breast cancer by analyzing the efficacy of immune checkpoint inhibitors (ICIs) and potential predictive biomarkers. Materials and Methods: To establish the murine triple-negative breast cancer… read more here.
Keywords: syngeneic; preclinical platform; breast cancer; model ... See more keywords