Preclinical safety evaluation of levonadifloxacin, a novel anti‐methicillin‐resistant Staphyloccocus aureus benzoquinolizine fluoroquinolone by intravenous and oral administration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4300
Abstract: Fluoroquinolone (FQ) antibacterials have drawn heightened attention from various international regulatory agencies due to their class‐specific side effects. Levonadifloxacin is a novel broad spectrum benzoquinolizine FQ active against methicillin‐resistant Staphyloccocus aureus (MRSA). Owing to FQ‐associated… read more here.
Keywords: toxicology; safety; preclinical safety; wck 771 ... See more keywords
Preclinical safety and efficacy of 24R,25-dihydroxyvitamin D3 or lactosylceramide treatment to enhance fracture repair
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2020.03.013
Abstract: Background/Objective Cyp24a1-null mice deficient in 24,25(OH)2D3 display impaired callus formation during the endochondral phase of bone fracture repair. The 24,25(OH)2D3 metabolite acted by binding to the TLC domain containing 3B isoform 2 (TLCD3B2, previously named… read more here.
Keywords: fracture; treatment; preclinical safety; efficacy ... See more keywords
Preclinical safety assessment of a therapeutic human papillomavirus DNA vaccine combined with intravaginal interleukin-7 fused with hybrid Fc in female rats.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115406
Abstract: This study was conducted to establish the toxicological profile of combination treatment with therapeutic HPV DNA vaccines (GX-188E) and the long-acting form of recombinant human interleukin-7 fused with hybrid Fc (IL-7hyFc). GX-188E was administered intramuscularly… read more here.
Keywords: interleukin fused; safety assessment; fused hybrid; dna ... See more keywords
Preclinical safety and efficacy of andexanet alfa in animal models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13768
Abstract: Essentials There is currently no approved reversal agent for factor Xa (FXa) inhibitors Andexanet alfa has been developed to reverse the anticoagulant effects of FXa inhibitors Andexanet reduced blood loss and anticoagulation markers in rivaroxaban‐anticoagulated… read more here.
Keywords: alfa animal; efficacy andexanet; safety efficacy; preclinical safety ... See more keywords
Preclinical safety assessment of pathogen reduced red blood cells treated with amustaline and glutathione
Sign Up to like & getrecommendations! Published in 2020 at "Transfusion"
DOI: 10.1111/trf.15662
Abstract: The nucleic acid targeted pathogen reduction (PR) system utilizing amustaline (S‐303) and glutathione (GSH) is designed to inactivate blood‐borne pathogens and leukocytes in red blood cell concentrates (PR‐RBCC). Inactivation is attained after amustaline intercalates and… read more here.
Keywords: red blood; pathogen; preclinical safety; blood ... See more keywords
Preclinical safety assessment of photoluminescent metal quantum clusters stabilized with autologous serum proteins for host specific theranostics
Sign Up to like & getrecommendations! Published in 2023 at "Nanotheranostics"
DOI: 10.7150/ntno.82978
Abstract: Host derived serum proteome stabilised red-emitting gold quantum clusters (or Au-QC-NanoSera or QCNS) of size range ~2 nm have been synthesised in a first reported study. The host serum was taken from bovine, murine and… read more here.
Keywords: quantum; serum; preclinical safety; quantum clusters ... See more keywords