Investigation into MAO B–Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of (S)-Enantiomer of Indaneamine (RP101075) by MAO B
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000447
Abstract: Ozanimod, recently approved for treating relapsing multiple sclerosis, produced a disproportionate, active, MAO B–catalyzed metabolite (CC112273) that showed remarkable interspecies differences and led to challenges in safety testing. This study explored the kinetics of CC112273… read more here.
Keywords: mao mediated; mao; formation; preclinical species ... See more keywords
Preclinical species gene expression database: Development and meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1078050
Abstract: The evaluation of toxicity in preclinical species is important for identifying potential safety liabilities of experimental medicines. Toxicology studies provide translational insight into potential adverse clinical findings, but data interpretation may be limited due to… read more here.
Keywords: meta analysis; preclinical species; toxicology; gene expression ... See more keywords
Inhaled formulation and device selection: bridging the gap between preclinical species and first-in-human studies.
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutic delivery"
DOI: 10.4155/tde-2000-0000
Abstract: The factors that influence inhaled first-in-human (FIH) device and formulation selection often differ significantly from the factors that have influenced the preceding preclinical experiments and inhalation toxicology work. In order to minimize the risk of… read more here.
Keywords: formulation; preclinical species; device selection; first human ... See more keywords