Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-71779-1_6
Abstract: Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, inherited disease that leads to degeneration of Purkinje cells of the cerebellum and culminates in death 10-30 years after disease onset. SCA1 is caused by a CAG repeat… read more here.
Keywords: protein; ataxia type; spinocerebellar ataxia; preclinical studies ... See more keywords
Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03598-2
Abstract: Introduction Glioblastoma (GBM) has a survival rate of around 2 years with aggressive current standard of care. While other tumors have responded favorably to trials combining immunotherapy and chemotherapy, GBM remains uniformly deadly with minimal… read more here.
Keywords: preclinical studies; treatment outcomes; treatment; temozolomide treatment ... See more keywords
Common data elements and data management: Remedy to cure underpowered preclinical studies
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2016.11.010
Abstract: Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data collection… read more here.
Keywords: preclinical studies; research; data elements; common data ... See more keywords
Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Psychoactive Drugs"
DOI: 10.1080/02791072.2016.1260189
Abstract: ABSTRACT Harmine is a natural β-carboline alkaloid found in several botanical species, such as the Banisteriopsis caapi vine used in the preparation of the hallucinogenic beverage ayahuasca and the seeds of Syrian rue (Peganum harmala).… read more here.
Keywords: preclinical studies; harmine; natural carboline; carboline alkaloid ... See more keywords
Emerging neuroprotective interventions in periventricular leukomalacia - A systematic review of preclinical studies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2040479
Abstract: ABSTRACT Introduction Periventricular leukomalacia (PVL) is a result of various antenatal, intrapartum, or postnatal insults to the developing brain and is an important harbinger of cerebral palsy in preterm neonates. There is no proven therapy… read more here.
Keywords: periventricular leukomalacia; systematic review; neuroprotective interventions; pvl ... See more keywords
Preclinical Studies of the Nebulized Delivery of Liposomal Amphotericin B.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of aerosol medicine and pulmonary drug delivery"
DOI: 10.1089/jamp.2022.0003
Abstract: Background: Intravenous liposomal amphotericin B (L-AMB) has accompanying side effects that may be diminished when administering an inhaled form. Delivery systems for inhaled or aerosolized L-AMB vary, and there has not been a recent comparison… read more here.
Keywords: liposomal amphotericin; amb; studies nebulized; delivery ... See more keywords
Advances in 3D cell culture for liver preclinical studies.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab046
Abstract: The 3D cell culture model is an indispensable tool in the study of liver biology in the field of health and disease and the development of clinically relevant products for liver therapies. The 3D culture… read more here.
Keywords: preclinical studies; cell culture; advances cell; culture liver ... See more keywords
Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies.
Sign Up to like & getrecommendations! Published in 2021 at "Pain"
DOI: 10.1097/j.pain.0000000000002268
Abstract: ABSTRACT This narrative review represents an output from the International Association for the Study of Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based medicines (CBM) for pain management, informed by our… read more here.
Keywords: preclinical studies; endocannabinoid system; cannabinoids endocannabinoid; system modulators ... See more keywords
Preclinical studies and clinical trials on mesenchymal stem cell therapy for knee osteoarthritis: A systematic review on models and cell doses
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14306
Abstract: To provide a systematic analysis of the study design in knee osteoarthritis (OA) preclinical studies, focusing on the characteristics of animal models and cell doses, and to compare these to the characteristics of clinical trials… read more here.
Keywords: clinical trials; models cell; mesenchymal stem; cell doses ... See more keywords
Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies
Sign Up to like & getrecommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13817
Abstract: Prenatal alcohol exposure results in cognitive, behavioral, and neurological deficits in offspring. There is an urgent need for safe and effective treatments to overcome these effects. Maternal choline supplementation has been identified as a potential… read more here.
Keywords: alcohol exposure; preclinical studies; choline supplementation; exposure ... See more keywords
Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Periodontal Research"
DOI: 10.1111/jre.12566
Abstract: Osteoporosis is one of the most common skeletal disorders affecting a significant percentage of people worldwide. Research data suggested that systemic diseases such as osteoporosis could act as risk factors for osseointegration, jeopardizing the healing… read more here.
Keywords: osseointegration osteoporotic; preclinical studies; research; systematic review ... See more keywords