Silk Sericin in Dermatological Diseases: From Preclinical Studies to Future Clinical Applications
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular Bioscience"
DOI: 10.1002/mabi.202500058
Abstract: Biomaterials in medicine are becoming more widespread as a single or complementary treatment option. One such biomaterial is silk, comprised of two primary proteins: fibroin and sericin. Recently, sericin's anti‐inflammatory, antioxidant, moisturizing, elastase‐ and tyrosinase‐inhibiting… read more here.
Keywords: treatment; sericin dermatological; silk sericin; dermatological diseases ... See more keywords
Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-71779-1_6
Abstract: Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, inherited disease that leads to degeneration of Purkinje cells of the cerebellum and culminates in death 10-30 years after disease onset. SCA1 is caused by a CAG repeat… read more here.
Keywords: protein; ataxia type; spinocerebellar ataxia; preclinical studies ... See more keywords
IND-enabling preclinical studies of [11C]COU, a trapped metabolite PET radiotracer for monoamine oxidase-B
Sign Up to like & getrecommendations! Published in 2025 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-025-03496-0
Abstract: [11C]COU is a trapped metabolite radiotracer for in vivo analysis of Monoamine Oxidase B activity using positron emission tomography (PET) imaging. [11C]COU has the potential to quantify astrocytosis in the early stages of Alzheimer’s disease,… read more here.
Keywords: trapped metabolite; cou trapped; preclinical studies; 11c cou ... See more keywords
Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-025-01556-y
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra of the midbrain. With its incidence rising annually, the multi-mechanistic pathogenesis of PD… read more here.
Keywords: review; therapeutic potential; herbal interventions; interventions parkinson ... See more keywords
Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03598-2
Abstract: Introduction Glioblastoma (GBM) has a survival rate of around 2 years with aggressive current standard of care. While other tumors have responded favorably to trials combining immunotherapy and chemotherapy, GBM remains uniformly deadly with minimal… read more here.
Keywords: preclinical studies; treatment outcomes; treatment; temozolomide treatment ... See more keywords
Common data elements and data management: Remedy to cure underpowered preclinical studies
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2016.11.010
Abstract: Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data collection… read more here.
Keywords: preclinical studies; research; data elements; common data ... See more keywords
Fucoidan for Lung Cancer Therapy: A Review of Classification, Mechanisms, and Preclinical Studies
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c08144
Abstract: Lung cancer is one of the most common cancers, resulting in numerous deaths worldwide. It is classified into small-cell lung cancer and non-small cell lung cancer. The non-small cell lung cancer accounts for approximately 80%… read more here.
Keywords: lung cancer; cancer; cancer therapy; preclinical studies ... See more keywords
High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Data"
DOI: 10.1038/s41597-025-05619-z
Abstract: Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies commonly use mouse… read more here.
Keywords: brain; segmentation; tumor; preclinical studies ... See more keywords
The Exclusion Problem in Preclinical Studies: A Case of Epistemic Injustice?
Sign Up to like & getrecommendations! Published in 2024 at "Social Epistemology"
DOI: 10.1080/02691728.2024.2400082
Abstract: ABSTRACT Researchers in neuroscience and biomedicine tend to exclude female animal subjects from preclinical studies. As a result, they fail to consider sex as a biological variable (SABV) while testing some drug or treatment, and… read more here.
Keywords: women patients; claim; epistemic injustice; exclusion ... See more keywords
Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Psychoactive Drugs"
DOI: 10.1080/02791072.2016.1260189
Abstract: ABSTRACT Harmine is a natural β-carboline alkaloid found in several botanical species, such as the Banisteriopsis caapi vine used in the preparation of the hallucinogenic beverage ayahuasca and the seeds of Syrian rue (Peganum harmala).… read more here.
Keywords: preclinical studies; harmine; natural carboline; carboline alkaloid ... See more keywords
Emerging neuroprotective interventions in periventricular leukomalacia - A systematic review of preclinical studies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2040479
Abstract: ABSTRACT Introduction Periventricular leukomalacia (PVL) is a result of various antenatal, intrapartum, or postnatal insults to the developing brain and is an important harbinger of cerebral palsy in preterm neonates. There is no proven therapy… read more here.
Keywords: periventricular leukomalacia; systematic review; neuroprotective interventions; pvl ... See more keywords