A preclinical study of diffusion‐weighted MRI contrast as an early indicator of thermal ablation
Sign Up to like & getrecommendations! Published in 2020 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.28537
Abstract: Intraoperative T2‐weighted (T2‐w) imaging unreliably captures image contrast specific to thermal ablation after transcranial MR‐guided focused ultrasound surgery, impeding dynamic imaging feedback. Using a porcine thalamotomy model, we test the unproven hypothesis that intraoperative DWI… read more here.
Keywords: contrast; thermal ablation; study diffusion; diffusion weighted ... See more keywords
Preclinical Stroke Research and Translational Failure: A Bird's Eye View on Preventable Variables.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01083-6
Abstract: Despite achieving remarkable success in understanding the cellular, molecular and pathophysiological aspects of stroke, translation from preclinical research has always remained an area of debate. Although thousands of experimental compounds have been reported to be… read more here.
Keywords: research; stroke research; study; preclinical study ... See more keywords
Comparative strategies for stem cell biodistribution in a preclinical study
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0313-x
Abstract: Stem cell therapy represents the potential alternative effective strategy for some diseases that lack effective treatment currently. Correspondingly, it is crucial to establish high-sensitive and reliable quantification assay for tracing exogenous cell migration. In the… read more here.
Keywords: biodistribution; study; stem cell; hnscs ... See more keywords
Abstract 1103: Aspirin reduces the incidence of metastasis in a preclinical study ofBrafmutant colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1103
Abstract: Background. Aspirin is a well-studied chemopreventive agent for the prevention of conventional colorectal adenomas and cancer. Post hoc analyses of cardiovascular prevention trials demonstrate a long-term reduction in colorectal cancer incidence and mortality with aspirin… read more here.
Keywords: incidence; colorectal cancer; metastasis; cancer ... See more keywords
On the same page? A qualitative study protocol on collaboration in a multi-laboratory preclinical study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273077
Abstract: Introduction Medical advancements are slow to reach the patient bedside due to issues with knowledge translation from preclinical studies. Multi-laboratory preclinical studies are a promising strategy for addressing the methodological deficiencies that weaken the translational… read more here.
Keywords: multi laboratory; laboratory preclinical; preclinical study; study ... See more keywords
Preclinical study of a novel ingestible bleeding sensor for upper gastrointestinal bleeding.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical endoscopy"
DOI: 10.5946/ce.2022.293
Abstract: Background/Aims Upper gastrointestinal bleeding (UGIB) is a life-threatening condition that necessitates early identification and intervention and is associated with substantial morbidity, mortality, and socioeconomic burden. However, several diagnostic challenges remain regarding risk stratification and the… read more here.
Keywords: upper gastrointestinal; gastrointestinal bleeding; preclinical study; blood ... See more keywords