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   Articles with "precursor acute" as a keyword



Clinical Impact of Immunoglobulin Heavy Chain Clonality in Pediatric B‐Cell Precursor Acute Lymphoblastic Leukemia

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recommendations! Published in 2025 at "Cancer Medicine"

DOI: 10.1002/cam4.71336

Abstract: Recent advancements in risk stratification have greatly improved outcomes in pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). Despite favorable prognostic indicators, including the absence of cytogenetic abnormalities and minimal residual disease (MRD) negativity, relapse remains… read more here.

Keywords: cell precursor; acute lymphoblastic; lymphoblastic leukemia; precursor acute ... See more keywords

Integrated clinical genotype‐phenotype characteristics of early T‐cell precursor acute lymphoblastic leukemia

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recommendations! Published in 2022 at "Cancer"

DOI: 10.1002/cncr.34515

Abstract: Early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is a distinct subtype of T‐ALL with a unique immunophenotype and high treatment failure rate. The molecular genetic abnormalities and their prognostic impact in ETP‐ALL patients are poorly… read more here.

Keywords: cell precursor; precursor acute; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
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Prognostic significance of IKZF1 deletions and IKZF1plus profile in children with B-cell precursor acute lymphoblastic leukemia treated according to the ALL-IC BFM 2009 protocol.

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recommendations! Published in 2022 at "Hematological oncology"

DOI: 10.1002/hon.2973

Abstract: The strongest predictors of outcome in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are minimal residual disease (MRD) and specific molecular abnormalities. One unfavorable prognostic factor is the presence of IKZF1 gene aberrations, particularly when… read more here.

Keywords: precursor acute; protocol; treated according; cell precursor ... See more keywords
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Allogeneic HCT for adults with B-cell precursor acute lymphoblastic leukemia harboring IKZF1 gene mutations. A study by the Acute Leukemia Working Party of the EBMT

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recommendations! Published in 2020 at "Bone Marrow Transplantation"

DOI: 10.1038/s41409-020-01139-z

Abstract: The presence of IKZF1 gene mutations is associated with poor prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The goal of this retrospective study was to evaluate outcome of allogeneic hematopoietic cell transplantation (allo-HCT) in… read more here.

Keywords: gene mutations; precursor acute; ikzf1 gene; cell precursor ... See more keywords

Perspectives of Fc engineered antibodies in CD19 targeting immunotherapies in pediatric B-cell precursor acute lymphoblastic leukemia

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recommendations! Published in 2018 at "Oncoimmunology"

DOI: 10.1080/2162402x.2018.1448331

Abstract: ABSTRACT CD19 immunotherapies based on T cells opened new avenues in the treatment of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, Fc engineered CD19 antibodies may also bear great potential. In light of recent… read more here.

Keywords: precursor acute; lymphoblastic leukemia; cell precursor; acute lymphoblastic ... See more keywords

VANDA regimen followed by blinatumomab leads to favourable outcome in patients with Philadelphia chromosome‐negative B‐precursor acute lymphoblastic leukaemia in first relapse

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recommendations! Published in 2022 at "British Journal of Haematology"

DOI: 10.1111/bjh.18218

Abstract: Adults with relapsed or refractory B‐precursor acute lymphoblastic leukaemia (R/R BCP‐ALL) have very poor outcome. Blinatumomab as single agent has shown activity in R/R BCP‐ALL. We aimed to assess the activity of blinatumomab in concomitant… read more here.

Keywords: leukaemia; lymphoblastic leukaemia; precursor acute; acute lymphoblastic ... See more keywords
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The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols.

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recommendations! Published in 2023 at "British journal of haematology"

DOI: 10.1111/bjh.18852

Abstract: We investigated 390 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients treated according to NOPHO ALL 2008, regarding copy number alterations (CNA) of eight loci associated with adverse prognosis, including IKZF1. The impact on outcome… read more here.

Keywords: lymphoblastic leukaemia; cell precursor; precursor acute; risk ... See more keywords

Prenatal origin of NUTM1 gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia

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recommendations! Published in 2024 at "British Journal of Haematology"

DOI: 10.1111/bjh.19685

Abstract: Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B‐cell precursor Acute Lymphoblastic Leukaemia (BCP‐ALL). In this study we had the unique… read more here.

Keywords: cell precursor; acute lymphoblastic; gene; precursor acute ... See more keywords

Clinical, biological, and outcome features of P2RY8‐CRLF2 and CRLF2 over‐expression in pediatric B‐cell precursor acute lymphoblastic leukemia according to the CCLG‐ALL 2008 and 2018 protocol

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recommendations! Published in 2023 at "European Journal of Haematology"

DOI: 10.1111/ejh.13948

Abstract: CRLF2 alterations are associated with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). This study aimed to explore the clinical, biological, and outcome features of pediatric BCP‐ALL with CRLF2 abnormalities. read more here.

Keywords: crlf2; clinical biological; cell precursor; precursor acute ... See more keywords

Abstract 2587: AHR-WLS complex correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-2587

Abstract: B cell precursor acute lymphoblastic leukemia (BCP ALL), the most common childhood cancer, is a malignant disorder that originates from the lymphoid precursor cells committed to B-cell lineage in the bone marrow. Although genetic abnormalities… read more here.

Keywords: cell; leukemia; cell precursor; precursor acute ... See more keywords

Incorporation of immunotherapy into frontline treatment for adults with B-cell precursor acute lymphoblastic leukemia.

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood.2023022921

Abstract: Although complete remission rates in adults with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) have improved over the last two decades, it is still inferior to that of the pediatric population and once in remission, the… read more here.

Keywords: cell precursor; treatment; acute lymphoblastic; chemotherapy ... See more keywords