Integrated clinical genotype‐phenotype characteristics of early T‐cell precursor acute lymphoblastic leukemia
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DOI: 10.1002/cncr.34515
Abstract: Early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is a distinct subtype of T‐ALL with a unique immunophenotype and high treatment failure rate. The molecular genetic abnormalities and their prognostic impact in ETP‐ALL patients are poorly… read more here.
Keywords: cell precursor; precursor acute; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Prognostic significance of IKZF1 deletions and IKZF1plus profile in children with B-cell precursor acute lymphoblastic leukemia treated according to the ALL-IC BFM 2009 protocol.
Sign Up to like & getrecommendations! Published in 2022 at "Hematological oncology"
DOI: 10.1002/hon.2973
Abstract: The strongest predictors of outcome in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are minimal residual disease (MRD) and specific molecular abnormalities. One unfavorable prognostic factor is the presence of IKZF1 gene aberrations, particularly when… read more here.
Keywords: precursor acute; protocol; treated according; cell precursor ... See more keywords
Allogeneic HCT for adults with B-cell precursor acute lymphoblastic leukemia harboring IKZF1 gene mutations. A study by the Acute Leukemia Working Party of the EBMT
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DOI: 10.1038/s41409-020-01139-z
Abstract: The presence of IKZF1 gene mutations is associated with poor prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The goal of this retrospective study was to evaluate outcome of allogeneic hematopoietic cell transplantation (allo-HCT) in… read more here.
Keywords: gene mutations; precursor acute; ikzf1 gene; cell precursor ... See more keywords
Perspectives of Fc engineered antibodies in CD19 targeting immunotherapies in pediatric B-cell precursor acute lymphoblastic leukemia
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DOI: 10.1080/2162402x.2018.1448331
Abstract: ABSTRACT CD19 immunotherapies based on T cells opened new avenues in the treatment of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, Fc engineered CD19 antibodies may also bear great potential. In light of recent… read more here.
Keywords: precursor acute; lymphoblastic leukemia; cell precursor; acute lymphoblastic ... See more keywords
VANDA regimen followed by blinatumomab leads to favourable outcome in patients with Philadelphia chromosome‐negative B‐precursor acute lymphoblastic leukaemia in first relapse
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DOI: 10.1111/bjh.18218
Abstract: Adults with relapsed or refractory B‐precursor acute lymphoblastic leukaemia (R/R BCP‐ALL) have very poor outcome. Blinatumomab as single agent has shown activity in R/R BCP‐ALL. We aimed to assess the activity of blinatumomab in concomitant… read more here.
Keywords: leukaemia; lymphoblastic leukaemia; precursor acute; acute lymphoblastic ... See more keywords
The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18852
Abstract: We investigated 390 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients treated according to NOPHO ALL 2008, regarding copy number alterations (CNA) of eight loci associated with adverse prognosis, including IKZF1. The impact on outcome… read more here.
Keywords: lymphoblastic leukaemia; cell precursor; precursor acute; risk ... See more keywords
Clinical, biological, and outcome features of P2RY8‐CRLF2 and CRLF2 over‐expression in pediatric B‐cell precursor acute lymphoblastic leukemia according to the CCLG‐ALL 2008 and 2018 protocol
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DOI: 10.1111/ejh.13948
Abstract: CRLF2 alterations are associated with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). This study aimed to explore the clinical, biological, and outcome features of pediatric BCP‐ALL with CRLF2 abnormalities. read more here.
Keywords: crlf2; clinical biological; cell precursor; precursor acute ... See more keywords
Abstract 2587: AHR-WLS complex correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia
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DOI: 10.1158/1538-7445.am2023-2587
Abstract: B cell precursor acute lymphoblastic leukemia (BCP ALL), the most common childhood cancer, is a malignant disorder that originates from the lymphoid precursor cells committed to B-cell lineage in the bone marrow. Although genetic abnormalities… read more here.
Keywords: cell; leukemia; cell precursor; precursor acute ... See more keywords
High tumor burden before blinatumomab has a negative impact on the outcome of adult patients with B-cell precursor acute lymphoblastic leukemia. A real-world study by the GRAALL
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.280078
Abstract: Blinatumomab is a bispecific T-cell engager approved for B-cell precursor acute lymphoblastic leukemia (B-ALL) with persistent minimal residual disease (MRD) or in relapse. The prognostic impact of tumor load has been suggested before other immunotherapies… read more here.
Keywords: blinatumomab; cell precursor; precursor acute; relapse ... See more keywords
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement
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DOI: 10.3324/haematol.2021.280557
Abstract: Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukemia (BCP-ALL) carries an immunoglobulin-MYC rearrangement (IG-MYC-r). This can result in diagnostic confusion with Burkitt lymphoma/leukemia and use of individualized treatment schedules of unproven efficacy. Here we compare… read more here.
Keywords: acute lymphoblastic; leukemia; cell precursor; precursor acute ... See more keywords
The role of microenvironment in the initiation and evolution of B-cell precursor acute lymphoblastic leukemia
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DOI: 10.3389/fonc.2023.1150612
Abstract: B cell precursor acute lymphoblastic leukemia (BCP-ALL) is a malignant disorder of immature B lineage immune progenitors and is the commonest cancer in children. Despite treatment advances it remains a leading cause of death in… read more here.
Keywords: cell; leukemia; cell precursor; precursor acute ... See more keywords