Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23567
Abstract: During development or after brain injury, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes to supplement the number of oligodendrocytes. Although mechanisms of OPC differentiation have been extensively examined, the role of epigenetic regulators, such as… read more here.
Keywords: epigenetic regulators; differentiation; differential roles; opc differentiation ... See more keywords
Early cortical oligodendrocyte precursor cells are transcriptionally distinct and lack synaptic connections.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24388
Abstract: Oligodendrocyte precursor cells (OPCs) generate oligodendrocytes, a process that may be tuned by neuronal activity, possibly via synaptic connections to OPCs. However, a developmental role of synaptic signaling to OPCs has so far not been… read more here.
Keywords: synaptic connections; postnatal opcs; precursor cells; opcs ... See more keywords
Role of the hydrogen sulfide‐releasing donor ADT‐OH in the regulation of mammal neural precursor cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30726
Abstract: Neural precursor cells (NPCs) generate new neurons to supplement neuronal loss as well as to repair damaged neural circuits. Therefore, NPCs have potential applications in a variety of neurological diseases, such as spinal cord injury,… read more here.
Keywords: precursor cells; sulfide releasing; hydrogen sulfide; neural precursor ... See more keywords
Effects of myogenic precursor cells (C2C12) transplantation and low‐level laser therapy on muscle repair
Sign Up to like & getrecommendations! Published in 2018 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.22798
Abstract: The aim of the present study was to evaluate the effects of myoblast inoculation in combination with photobiomodulation therapy (PBMT) on skeletal muscle tissue following injury. read more here.
Keywords: muscle; effects myogenic; therapy; cells c2c12 ... See more keywords
First Clinical Report on the Treatment of Parkinson's Disease with Fetal Midbrain Precursor Cells
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29316
Abstract: Because human fetal ventral mesencephalic tissue grafts provide promising results in ameliorating Parkinson's disease–implicated motor dysfunctions, human fetal midbrain‐derived dopamine neuronal precursor cells are considered good candidates for cell‐based therapy for Parkinson's disease in that… read more here.
Keywords: precursor cells; disease; parkinson disease; fetal midbrain ... See more keywords
Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4471-4
Abstract: Aims/hypothesisSubcutaneous adipocyte hypertrophy is associated with insulin resistance and increased risk of type 2 diabetes, and predicts its future development independent of obesity. In humans, subcutaneous adipose tissue hypertrophy is a consequence of impaired adipocyte… read more here.
Keywords: nih 3t3; obesity; gene; precursor cells ... See more keywords
Continuous Immune-Modulatory Effects of Human Olig2+ Precursor Cells Attenuating a Chronic-Active Model of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01802-7
Abstract: Neuroglial precursor cells (NPC) possess immune-modulatory properties by which they prevent immune-mediated injury in experimental autoimmune encephalomyelitis (EAE). It is unclear whether cell transplantation in a clinical-relevant setup induces ongoing therapeutic effects in a chronic-active… read more here.
Keywords: chronic active; active model; precursor cells; immune modulatory ... See more keywords
Human skin-derived precursor cells xenografted in aganglionic bowel.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2020.03.006
Abstract: PURPOSE One in 5000 newborns is diagnosed with Hirschsprung disease each year in the United States. The potential of employing neural crest stem cells to restore the enteric nervous system has been investigated. Skin-derived precursor… read more here.
Keywords: skin derived; cells xenografted; human skin; derived precursor ... See more keywords
Dexamethasone primes adipocyte precursor cells for differentiation by enhancing adipogenic competency.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118363
Abstract: AIM Dexamethasone (DXM) is a synthetic glucocorticoid whose effects in early and terminal adipogenesis have been addressed. In this study, we evaluated if DXM affects adipocyte precursor cells (APCs), priming them for further adipogenic differentiation.… read more here.
Keywords: adipocyte precursor; competency; dexamethasone primes; differentiation ... See more keywords
Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2018.10.021
Abstract: Exposure to herbicides can induce long-term chronic adverse effects such as respiratory diseases, malignancies and neurodegenerative diseases. Oxadiazon, a pre-emergence or early post-emergence herbicide, despite its low acute toxicity, may induce liver cancer and may… read more here.
Keywords: role; precursor cells; activity; expression activity ... See more keywords
Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-021-00369-0
Abstract: Intraocular medulloepithelioma (IO-MEPL) is a rare embryonal ocular neoplasm, prevalently occurring in children. IO-MEPLs share histomorphological features with CNS embryonal tumors with multilayered rosettes (ETMRs), referred to as intracranial medulloepitheliomas. While Sonic hedgehog (SHH) and… read more here.
Keywords: wnt signaling; wnt; intraocular medulloepithelioma; sonic hedgehog ... See more keywords