Enhancement of sensitivity and quantification quality in the LC–MS/MS measurement of large biomolecules with sum of MRM (SMRM)
Sign Up to like & getrecommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03829-z
Abstract: Liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS) provides a simple and efficient means for the measurement of analytes in biological matrices with high selectivity and specificity. LC–MS/MS plays an important role in the… read more here.
Keywords: mrm smrm; ion; precursor ion; sensitivity ... See more keywords
Precursor Ion Scan Mode-Based Strategy for Fast Screening of Polyether Ionophores by Copper-Induced Gas-Phase Radical Fragmentation Reactions.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b02855
Abstract: The potential of copper(II) to induce gas-phase fragmentation reactions in macrotetrolides, a class of polyether ionophores produced by Streptomyces species, was investigated by accurate-mass electrospray tandem mass spectrometry (ESI-MS/MS). Copper(II)/copper(I) transition directly induced production of… read more here.
Keywords: precursor ion; copper; fragmentation reactions; ion scan ... See more keywords
Axinellasins A-D, Immunosuppressive Cycloheptapeptide Diastereomers, Discovered via a Precursor Ion Scanning-Supercritical Fluid Chromatography Strategy from the Marine Sponge Axinella species.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04309
Abstract: The precursor ion scanning-supercritical fluid chromatography (PI-SFC) method was applied to explore new methionine sulfoxide-containing cycloheptapeptides, axinellasins A-D (1-4), from the marine sponge Axinella sp. Their structures, including absolute configurations, were elucidated by detailed spectroscopic… read more here.
Keywords: precursor ion; ion scanning; fluid chromatography; supercritical fluid ... See more keywords
Detecting Fentanyl Analogs in Urine Using Precursor Ion Scan Mode.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkab002
Abstract: The opioid crisis has led many providers to inquire about the capabilities of urine drug testing to detect contemporary compounds such as fentanyl and fentanyl analogs. However, current methods for clinical urine drug testing, including… read more here.
Keywords: precursor ion; fentanyl analogs; detecting fentanyl; ion scan ... See more keywords