A Predicted Structure of the Angiomotin Lipid Binding Domain
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DOI: 10.1016/j.bpj.2016.11.336
Abstract: Amots are a family of adapter proteins that modulate cellular polarity, differentiation, proliferation, and migration. Amot family members also have a characteristic lipid-binding domain, the coiled coil homology (ACCH) Domain that selectively targets the protein… read more here.
Keywords: lipid binding; predicted structure; binding domain; domain ... See more keywords
A predicted structure of NADPH Oxidase 1 identifies key components of ROS generation and strategies for inhibition
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DOI: 10.1371/journal.pone.0285206
Abstract: NADPH oxidase 1 (NOX1) is primarily expressed in epithelial cells and responsible for local generation of reactive oxygen species (ROS). By specifically manipulating the local redox microenvironment, NOX1 actively engages in epithelial immunity, especially in… read more here.
Keywords: nadph oxidase; structure; ros generation; generation ... See more keywords
Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors
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DOI: 10.3389/fmolb.2023.1171143
Abstract: Virtual screening is a widely used tool for drug discovery, but its predictive power can vary dramatically depending on how much structural data is available. In the best case, crystal structures of a ligand-bound protein… read more here.
Keywords: cryptic pocket; structure; ppm1d; predicted structure ... See more keywords
A 3D–Predicted Structure of the Amine Oxidase Domain of Lysyl Oxidase–Like 2
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DOI: 10.3390/ijms232113385
Abstract: Lysyl oxidase–like 2 (LOXL2) has been recognized as an attractive drug target for anti–fibrotic and anti–tumor therapies. However, the structure–based drug design of LOXL2 has been very challenging due to the lack of structural information… read more here.
Keywords: oxidase like; structure; lysyl oxidase; oxidase ... See more keywords