BayeStab: Predicting effects of mutations on protein stability with uncertainty quantification
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4467
Abstract: Predicting protein thermostability change upon mutation is crucial for understanding diseases and designing therapeutics. However, accurately estimating Gibbs free energy change of the protein remained a challenge. Some methods struggle to generalize on examples with… read more here.
Keywords: bayestab predicting; uncertainty; predicting effects; bayestab ... See more keywords
FABIAN-variant: predicting the effects of DNA variants on transcription factor binding
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac393
Abstract: Abstract While great advances in predicting the effects of coding variants have been made, the assessment of non-coding variants remains challenging. This is especially problematic for variants within promoter regions which can lead to over-expression… read more here.
Keywords: transcription; predicting effects; transcription factor; fabian variant ... See more keywords
Predicting the effects of multiple global change drivers on microbial communities remains challenging
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DOI: 10.1111/gcb.16303
Abstract: Microbial communities in many ecosystems are facing a broad range of global change drivers, such as nutrient enrichment, chemical pollution, and temperature change. These drivers can cause changes in the abundance of taxa, the composition… read more here.
Keywords: change drivers; change; predicting effects; global change ... See more keywords
Corrigendum: Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.668861
Abstract: [This corrects the article DOI: 10.3389/fphar.2020.591854.]. read more here.
Keywords: corrigendum predicting; predicting effects; cyp2c19 carboxylesterases; carboxylesterases vicagrel ... See more keywords