Predicting functional effects of ion channel variants using new phenotypic machine learning methods
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010959
Abstract: Missense variants in genes encoding ion channels are associated with a spectrum of severe diseases. Variant effects on biophysical function correlate with clinical features and can be categorized as gain- or loss-of-function. This information enables… read more here.
Keywords: functional effects; machine; predicting functional; machine learning ... See more keywords
Predicting Functional Effects of Synonymous Variants: A Systematic Review and Perspectives
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00914
Abstract: Recent advances in high-throughput experimentation have put the exploration of genome sequences at the forefront of precision medicine. In an effort to interpret the sequencing data, numerous computational methods have been developed for evaluating the… read more here.
Keywords: synonymous variants; ssnv effects; variants systematic; effects synonymous ... See more keywords
Predicting Functional Connectivity From Observed and Latent Structural Connectivity via Eigenvalue Mapping
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.810111
Abstract: Understanding how complex dynamic activity propagates over a static structural network is an overarching question in the field of neuroscience. Previous work has demonstrated that linear graph-theoretic models perform as well as non-linear neural simulations… read more here.
Keywords: connectivity; predicting functional; structural connectivity; observed latent ... See more keywords
Validation of Screening Tools for Predicting the Risk of Functional Decline in Hospitalized Elderly Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19116685
Abstract: Background: Functional decline and increased dependence on others are common health issues among hospitalized elderly patients. However, a well-validated screening tool for predicting functional decline in elderly patients is still lacking. The current study therefore… read more here.
Keywords: decline; elderly patients; hospitalized elderly; predicting functional ... See more keywords