Predicting 3D genome folding from DNA sequence with Akita
Sign Up to like & getrecommendations! Published in 2020 at "Nature methods"
DOI: 10.1038/s41592-020-0958-x
Abstract: In interphase, the human genome sequence folds in three dimensions into a rich variety of locus-specific contact patterns. Cohesin and CTCF are key regulators; perturbing the levels of either greatly disrupts genome-wide folding as assayed… read more here.
Keywords: genome folding; predicting genome; folding dna; dna sequence ... See more keywords
Predicting Genome Architecture: Challenges and Solutions
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.617202
Abstract: Genome architecture plays a pivotal role in gene regulation. The use of high-throughput methods for chromatin profiling and 3-D interaction mapping provide rich experimental data sets describing genome organization and dynamics. These data challenge development… read more here.
Keywords: predicting genome; challenges solutions; architecture challenges; genome architecture ... See more keywords