Computational Prediction and Experimental Validation of a Bridged Cation Intermediate in Akanthomycin Biosynthesis.
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DOI: 10.1021/jacs.2c02288
Abstract: Here we report a computation-driven chemoenzymatic synthesis and biosynthesis of the natural product deoxyakanthomycin, an atropisomeric pyridone natural product that features a 7-membered carbocycle with five stereocenters, one of which a quaternary center. The one-step… read more here.
Keywords: experimental validation; biosynthesis; cation; computational prediction ... See more keywords