Prediction of Human Eye Fixation by a Single Filter
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Signal Processing Systems"
DOI: 10.1007/s11265-016-1131-8
Abstract: Saliency modeling has played an important part in computer vision studies over the past 30 years. Many state-of-the-art models adopted complex mathematical and machine learning theories. In this paper, a simple and effective visual attention model… read more here.
Keywords: eye fixation; human eye; prediction human;
In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00300
Abstract: Human pharmacokinetics is of great significance in the selection of drug candidates, and in silico estimation of pharmacokinetic parameters in the early stage of drug development has become the trend of drug research owing to… read more here.
Keywords: prediction human; human intravenous; accuracy; silico prediction ... See more keywords
Prediction of human miRNA target genes using computationally reconstructed ancestral mammalian sequences
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1085
Abstract: MicroRNAs (miRNA) are short single-stranded RNA molecules derived from hairpin-forming precursors that play a crucial role as post-transcriptional regulators in eukaryotes and viruses. In the past years, many microRNA target genes (MTGs) have been identified… read more here.
Keywords: target genes; target; mirna target; prediction human ... See more keywords
Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Science"
DOI: 10.1111/cts.12649
Abstract: Prediction of human pharmacokinetics (PK) based on preclinical information for antibody–drug conjugates (ADCs) provide important insight into first‐in‐human (FIH) study design. This retrospective analysis was conducted to identify an appropriate scaling method to predict human… read more here.
Keywords: allometric scaling; human pharmacokinetics; prediction human; antibody drug ... See more keywords
Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000784
Abstract: The utilization of in vitro data to predict drug pharmacokinetics (PK) in vivo has been a consistent practice in early drug discovery for decades. However, its success is hampered by mispredictions attributed to uncharacterized biological… read more here.
Keywords: clearance; drug discovery; empirical scalars; prediction human ... See more keywords
ADME, Pharmacokinetic Scaling, Pharmacodynamic and Prediction of Human Dose and Regimen of Novel Antiviral Drugs
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041212
Abstract: The search for new drugs is an extremely time-consuming and expensive endeavour. Much of that time and money go into generating predictive human pharmacokinetic profiles from preclinical efficacy and safety animal data. These pharmacokinetic profiles… read more here.
Keywords: pharmacodynamic prediction; pharmacokinetic scaling; prediction human; adme pharmacokinetic ... See more keywords