A predictive probability interim design for phase II clinical trials with continuous endpoints.
Sign Up to like & getrecommendations! Published in 2018 at "Statistics in medicine"
DOI: 10.1002/sim.7659
Abstract: Molecular targeted therapies come often with lower toxicity profiles than traditional cytotoxic treatments, thus shifting drug development paradigm into establishing evidence of biological activity, target modulation, and pharmacodynamics effects of these therapies in early phase… read more here.
Keywords: phase; probability interim; continuous endpoints; predictive probability ... See more keywords
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial.
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/tcr.2019.05.17
Abstract: Background Bayesian predictive probability design, with a binary endpoint, is gaining attention for the phase II trial due to its innovative strategy. To make the Bayesian design more accessible, we elucidate this Bayesian approach with… read more here.
Keywords: predictive probability; probability; bayesian predictive; trial ... See more keywords
Bayesian Predictive Distribution for a Negative Binomial Model
Sign Up to like & getrecommendations! Published in 2019 at "Mathematical Methods of Statistics"
DOI: 10.3103/s1066530719010010
Abstract: Estimation of the predictive probability function of a negative binomial distribution is addressed under the Kullback—Leibler risk. An identity that relates Bayesian predictive probability estimation to Bayesian point estimation is derived. Such identities are known… read more here.
Keywords: negative binomial; distribution negative; predictive probability; bayesian predictive ... See more keywords