MBD4 deficiency is predictive of response to immune checkpoint inhibitors in metastatic uveal melanoma patients.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of cancer"
DOI: 10.1200/jco.2022.40.16_suppl.e21601
Abstract: BACKGROUND MBD4 mutations have been reported in uveal melanomas, acute myeloid leukemias, colorectal adenocarcinomas, gliomas, and spiradenocarcinomas and cause a hypermutated phenotype. Although metastatic uveal melanomas (mUM) are usually resistant to immune checkpoint inhibitors (ICI),… read more here.
Keywords: predictive response; checkpoint inhibitors; immune checkpoint; metastatic uveal ... See more keywords
Cellular and Molecular Biomarkers Predictive of Response to Immunotherapy in Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.826768
Abstract: Immunotherapy has without question revolutionized the treatment of both hematologic and solid malignancies. Over the last several years novel strategies are being developed to incorporate these groundbreaking therapies into the care of patients with AML.… read more here.
Keywords: predictive response; immunotherapy; molecular biomarkers; biomarkers predictive ... See more keywords