Genetic predisposition to cancers in children and adolescents
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000001197
Abstract: Purpose of review Childhood cancer is rare, but it remains the leading cause of disease-related mortality among children 1–14 years of age. As exposure to environmental factors is lower in children, inherited genetic factors become an… read more here.
Keywords: predisposition syndromes; predisposition; predisposition cancers; genetic predisposition ... See more keywords
Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17247
Abstract: Inherited predisposition to haematopoietic malignancies, due to deleterious germline variants in a variety of genes, is an important clinical entity with implications for the health and management of patients and their family members. Unfortunately, there… read more here.
Keywords: malignancies overcoming; predisposition; haematopoietic malignancies; predisposition haematopoietic ... See more keywords
Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Korean Neurosurgical Society"
DOI: 10.3340/jkns.2018.0031
Abstract: Germline mutations in cancer causing genes result in high risk of developing cancer throughout life. These cancer predisposition syndromes (CPS) are especially prevalent in childhood brain tumors and impact both the patient’s and other family… read more here.
Keywords: pediatric high; high grade; cancer predisposition; grade gliomas ... See more keywords
Nonmalignant Features Associated with Inherited Colorectal Cancer Syndromes-Clues for Diagnosis
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DOI: 10.3390/cancers14030628
Abstract: Simple Summary Familiarity with nonmalignant features and comorbidities of cancer predisposition syndromes may raise awareness and assist clinicians in the diagnosis and interpretation of molecular test results. Genetic predisposition to colorectal cancer (CRC) should be… read more here.
Keywords: predisposition syndromes; nonmalignant features; diagnosis; colorectal cancer ... See more keywords
Diagnostic Strategies and Algorithms for Investigating Cancer Predisposition Syndromes in Children Presenting with Malignancy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153741
Abstract: Simple Summary Here we provide an overview of several genetically determined conditions that predispose to the development of solid and hematologic malignancies in children. Diagnosing these conditions, whose prevalence is estimated around 10% in children… read more here.
Keywords: predisposition syndromes; clinical screening; screening tools; cancer predisposition ... See more keywords