Biotransformation of prednisone and dexamethasone by cytochrome P450 based systems - Identification of new potential drug candidates.
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DOI: 10.1016/j.jbiotec.2016.12.011
Abstract: Prednisone and dexamethasone are synthetic glucocorticoids widely used as anti-inflammatory and immunosuppressive drugs. Since their hydroxylated derivatives could serve as novel potential drug candidates, our aim was to investigate their biotransformation by the steroid hydroxylase… read more here.
Keywords: prednisone; drug candidates; prednisone dexamethasone; potential drug ... See more keywords
Clinical Experience of Steroid Switch from Prednisone to Dexamethasone in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone Acetate
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DOI: 10.1159/000509882
Abstract: Objective: To evaluate the therapeutic efficacy of a steroid switch from prednisone to dexamethasone in Asians with metastatic castration-resistant prostate cancer (mCRPC) that progressed after docetaxel chemotherapy. Methods: This study included postdocetaxel patients with mCRPC… read more here.
Keywords: prednisone; prostate; steroid switch; switch prednisone ... See more keywords