A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer.
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DOI: 10.1038/s41467-021-27055-4
Abstract: Amplification and overexpression of the SOX2 oncogene represent a hallmark of squamous cancers originating from diverse tissue types. Here, we find that squamous cancers selectively amplify a 3' noncoding region together with SOX2, which harbors… read more here.
Keywords: expression; predominant enhancer; squamous cancer; enhancer ... See more keywords