Efficient siRNA transfer to knockdown a placenta specific lncRNA using RGD‐modified nano‐liposome: A new preeclampsia‐like mouse model
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.05.001
Abstract: Graphical abstract Figure. No Caption available. &NA; Preeclampsia is one of the most serious pregnancy complications. Many animal models have already been developed by researchers to study the pathogenesis and treatment of preeclampsia. However, most… read more here.
Keywords: preeclampsia like; placenta; rgd lip; model ... See more keywords
Activation of the cholinergic anti-inflammatory pathway by nicotine ameliorates lipopolysaccharide-induced preeclampsia-like symptoms in pregnant rats.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2016.11.003
Abstract: INTRODUCTION Preeclampsia (PE) exerts a more intense systemic inflammatory response than normal pregnancy. Recently, the role of the cholinergic anti-inflammatory pathway (CAP) in regulating inflammation has been extensively studied. The aim of this study was… read more here.
Keywords: symptoms pregnant; preeclampsia like; induced preeclampsia; pregnant rats ... See more keywords
Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Placenta"
DOI: 10.1016/j.placenta.2022.03.007
Abstract: INTRODUCTION Clinical studies suggest that early pregnancy is the critical window for the prevention of preeclampsia by low-dose aspirin (LDA). Abnormal extravillous trophoblast (EVT) cell invasion and spiral artery remodeling during early placentation have been… read more here.
Keywords: induced preeclampsia; preeclampsia like; dose aspirin; low dose ... See more keywords
Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.10849
Abstract: Endothelin-1 (ET-1) is implicated in the pathophysiology of preeclampsia. An association between an EDN1 gene polymorphism with high ET-1 and preeclampsia was reported in humans, but their cause and effect relationships have not been defined.… read more here.
Keywords: preeclampsia like; causative effects; blood pressure; preeclampsia ... See more keywords
Natural flavonoid quercetin enhances the anti-inflammatory effects of aspirin in a preeclampsia-like rat model induced by lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220513111637
Abstract: BACKGROUND Preeclampsia is a disorder of hypertension and proteinuria accompanied by abnormal inflammatory responses. Both aspirin and quercetin possess anti-inflammatory and anti-hypertensive properties. A low dose of aspirin is recommended for the prevention of preeclampsia… read more here.
Keywords: quercetin; preeclampsia; anti inflammatory; aspirin preeclampsia ... See more keywords
Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032149
Abstract: Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-binding protein 2 (ID2). Asb4−/− mice on… read more here.
Keywords: elevates id2; insulin elevates; like phenotypes; mice ... See more keywords
Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats
Sign Up to like & getrecommendations! Published in 2018 at "Turkish journal of medical sciences"
DOI: 10.3906/sag-1807-254
Abstract: Background/aim Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic,… read more here.
Keywords: uterine arteries; renal uterine; preeclampsia like; aortic renal ... See more keywords
Effects of Rapamycin on Clinical Manifestations and Blood Lipid Parameters in Different Preeclampsia-like Mouse Models
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DOI: 10.4103/0366-6999.204924
Abstract: Background: The pathogenesis of some types of preeclampsia is related to fatty acid oxidation disorders. Rapamycin can regulate fatty acid metabolism. This study aimed to investigate the effects of rapamycin on the clinical manifestations and… read more here.
Keywords: mouse models; preeclampsia like; group; blood ... See more keywords