Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100941
Abstract: Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds to sterols… read more here.
Keywords: phase; phase separation; cholesterol disordered; disordered domains ... See more keywords
Cardiolipin, and not monolysocardiolipin, preferentially binds to the interface of complexes III and IV
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1101/2022.07.21.500943
Abstract: The mitochondrial electron transport chain comprises a series of protein complexes embedded in the inner mitochondrial membrane that generate a proton motive force via oxidative phosphorylation, ultimately generating ATP. These protein complexes can oligomerize to… read more here.
Keywords: preferentially binds; civ; monolysocardiolipin preferentially; cardiolipin monolysocardiolipin ... See more keywords
Cannabidiol preferentially binds TRPV2: a novel mechanism of action
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.335821
Abstract: Plants from the genus Cannabis , and strains of Cannabis sativa in particular, have been used in medicine since ancient times. The Cannabis plant contains more than 500 chemical compounds, with two main phytocannabinoids consisting… read more here.
Keywords: preferentially binds; binds trpv2; cannabidiol; novel mechanism ... See more keywords