Differential Binding and Conformational Dynamics of Tau Microtubule-Binding Repeats with a Preformed Amyloid-β Fibril Seed.
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DOI: 10.1021/acschemneuro.3c00014
Abstract: Both senile plaques formed by amyloid-β (Aβ) and neurofibrillary tangles (NFTs) comprised of tau are pathological hallmarks of Alzheimer's disease (AD). The accumulation of NFTs better correlates with the loss of cognitive function than senile… read more here.
Keywords: microtubule binding; fibril seed; preformed amyloid; seed ... See more keywords