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   Articles with "prefusion" as a keyword



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Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.

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recommendations! Published in 2021 at "Immunity"

DOI: 10.1016/j.immuni.2021.03.004

Abstract: An effective vaccine for respiratory syncytial virus (RSV) is an unrealized public health goal. A single dose of the prefusion-stabilized fusion (F) glycoprotein subunit vaccine (DS-Cav1) substantially increases serum-neutralizing activity in healthy adults. We sought… read more here.

Keywords: prefusion stabilized; respiratory syncytial; syncytial virus; prefusion ... See more keywords

Design and characterization of a fusion glycoprotein vaccine for Respiratory Syncytial Virus with improved stability.

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recommendations! Published in 2018 at "Vaccine"

DOI: 10.1016/j.vaccine.2018.10.032

Abstract: Respiratory Syncytial Virus (RSV) infection is the leading cause of lower respiratory tract infection in both young children and older adults. Currently, there is no licensed vaccine available, and therapeutic options are limited. The infectious… read more here.

Keywords: respiratory syncytial; syncytial virus; prefusion; rsv ... See more keywords
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Stability of HA2 Prefusion Structure and pH-Induced Conformational Changes in the HA2 Domain of H3N2 Hemagglutinin.

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recommendations! Published in 2021 at "Biochemistry"

DOI: 10.1021/acs.biochem.1c00551

Abstract: Influenza hemagglutinin is the fusion protein that mediates fusion of the viral and host membranes through a large conformational change upon acidification in the developing endosome. The "spring-loaded" model has long been used to describe… read more here.

Keywords: change; prefusion; conformation; hemagglutinin ... See more keywords

Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV

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recommendations! Published in 2025 at "NPJ Vaccines"

DOI: 10.1038/s41541-025-01090-4

Abstract: Lassa virus (LASV) belongs to the Arenaviridae family and causes severe hemorrhagic fever in humans. Although many vaccine candidates for Lassa fever exist, no vaccines have been approved for clinical use currently. The precursor glycoprotein… read more here.

Keywords: gpcv2; prefusion; gpc trimer; prefusion gpc ... See more keywords

A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses

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recommendations! Published in 2024 at "Nature Microbiology"

DOI: 10.1038/s41564-024-01860-1

Abstract: Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease in infants and older people. Current RSV subunit vaccines are based on a fusion protein that is stabilized in the prefusion conformation and… read more here.

Keywords: prefusion; foldon free; respiratory syncytial; syncytial virus ... See more keywords

A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2

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recommendations! Published in 2025 at "Nature"

DOI: 10.1038/s41586-025-09438-5

Abstract: The nine human herpesviruses, including herpes simplex virus 1 and 2, human cytomegalovirus and Epstein–Barr virus, present a significant burden to global public health1. Their envelopes contain at least ten different glycoproteins, which are necessary for… read more here.

Keywords: prefusion; conformation; virus; nanobody specific ... See more keywords
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Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-77077-z

Abstract: The COVID-19 pandemic is a worldwide health emergency which calls for an unprecedented race for vaccines and treatment. In developing a COVID-19 vaccine, we applied technology previously used for MERS-CoV to produce a prefusion-stabilized SARS-CoV-2… read more here.

Keywords: prefusion; cpg 1018; cov spike; sars cov ... See more keywords

Cryo-EM structures of alphavirus conformational intermediates in low pH–triggered prefusion states

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2114119119

Abstract: Significance Eastern equine encephalitis virus (EEEV) is a neuroinvasive alphavirus that causes severe neurological diseases. Entry of alphaviruses requires host–virus membrane fusion in endosomes to release the RNA genome into the cytosol for virus replication.… read more here.

Keywords: fusion; membrane fusion; cryo structures; alphavirus conformational ... See more keywords

Effect of Slp4-a on Membrane Bending during Prefusion of Vesicles in Blood-Brain Barrier.

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recommendations! Published in 2022 at "Journal of biomechanical engineering"

DOI: 10.1115/1.4054985

Abstract: Vesicular exocytosis is a promising pathway for brain drug delivery through blood-brain barrier to treat neurodegenerative diseases. In vesicle exocytosis, the membrane fusion process is initiated by the calcium sensor protein named synaptotagmin-like protein4-a (Slp4-a).… read more here.

Keywords: calcium; blood brain; brain; prefusion ... See more keywords

The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion

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recommendations! Published in 2017 at "Journal of Virology"

DOI: 10.1128/jvi.01323-17

Abstract: ABSTRACT Respiratory syncytial virus (RSV) mediates host cell entry through the fusion (F) protein, which undergoes a conformational change to facilitate the merger of viral and host lipid membrane envelopes. The RSV F protein comprises… read more here.

Keywords: protein; prefusion; membrane fusion; heptad repeat ... See more keywords

A human cytomegalovirus prefusion-like glycoprotein B subunit vaccine elicits humoral immunity similar to that of postfusion gB in mice

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recommendations! Published in 2025 at "Journal of Virology"

DOI: 10.1128/jvi.02178-24

Abstract: ABSTRACT Human cytomegalovirus (HCMV) is the leading infectious cause of birth defects. Despite the global disease burden, there is no Food and Drug Administration (FDA)-approved HCMV vaccine. The most efficacious HCMV vaccine candidates to date… read more here.

Keywords: prefusion; prefusion like; cytomegalovirus; vaccine ... See more keywords