Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00023
Abstract: The multifunctional cytochrome P450 17A1 (CYP17A1) plays a crucial role in human steroid hormone synthesis (UniProtKB─P05093). It first carries out standard monooxygenase chemistry, converting pregnenolone (PREG) and progesterone (PROG) into 17OH-PREG and 17OH-PROG, utilizing a… read more here.
Keywords: cyp17a1; asparagine; preg; active site ... See more keywords
The Effect of P4 + eCG Estrus Induction Protocol during the Deep and the Transition Anestrous Period on the Reproductive Performance of Crossbred Dairy Goats
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DOI: 10.3390/biology9100311
Abstract: Simple Summary The effect of an ultra-short progesterone (P4) plus equine chorionic gonadotropin (eCG) based estrus induction protocol during deep seasonal anestrous, or the reproductive transition period upon reproductive performance in an arid environment (26°… read more here.
Keywords: ecg; effect; estrus induction; preg ... See more keywords
The Mechanism of Enantioselective Neurosteroid Actions on GABAA Receptors
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DOI: 10.3390/biom13020341
Abstract: The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not. This study was… read more here.
Keywords: ent allo; allo preg; gabaa receptors; ent ... See more keywords