Pregabalin for Neuropathic Pain and Itch in Recessive Dystrophic Epidermolysis Bullosa: A Randomized Crossover Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2024.3767
Abstract: Importance Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience neuropathic pain and itch. There is a lack of evidence on any treatment for these symptoms in patients with RDEB. Objectives To test the efficacy of… read more here.
Keywords: pain itch; pain; trial; pregabalin ... See more keywords
Initiation of Pregabalin vs Gabapentin and Development of Heart Failure
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.24451
Abstract: Key Points Question Is pregabalin associated with higher incidence of heart failure (HF) compared with gabapentin? Findings In this cohort study of 246 237 Medicare beneficiaries aged 65 to 89 years with noncancer chronic pain,… read more here.
Keywords: pregabalin; pregabalin gabapentin; initiation pregabalin; heart failure ... See more keywords
Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development Research"
DOI: 10.1002/ddr.21473
Abstract: Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as… read more here.
Keywords: pregabalin; pregabalin thioctic; motor; tocopherol ... See more keywords
GC-MS/MS detects potential pregabalin abuse in susceptible subjects' hair.
Sign Up to like & getrecommendations! Published in 2018 at "Drug testing and analysis"
DOI: 10.1002/dta.2347
Abstract: Pregabalin, a GABA analogue, binds to the alpha 2 delta subunit of voltage-dependent calcium channels. It is recognised as efficacious in pathologies such as epilepsy, neuropathic pain, and anxiety disorders. Since pregabalin prescriptions have increased… read more here.
Keywords: pregabalin; hair; potential pregabalin; pregabalin abuse ... See more keywords
Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.905
Abstract: Remifentanil is usually used for controlled hypotension during rhinoplasty under general anesthesia (G/A). One of the complications of the remifentanil is postoperative hyperalgesia. In this study, we compare the effectiveness of pregabalin with that of… read more here.
Keywords: remifentanil; prevention; induced hyperalgesia; remifentanil induced ... See more keywords
Highly regio- and enantioselective synthesis of chiral intermediate for pregabalin using one-pot bienzymatic cascade of nitrilase and amidase
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09857-1
Abstract: Nitrilase-mediated hydrolysis of isobutylsuccinonitrile (IBSN) is a highly attractive approach for (S)-3-cyano-5-methylhexanoic acid ((S)-CMHA), the critical chiral intermediate of pregabalin. In this study, a robust nitrilase from Arabis alpina (AaNIT) was screened and engineered. The… read more here.
Keywords: pregabalin; pot bienzymatic; nitrilase; bienzymatic cascade ... See more keywords
Preoperative oral pregabalin for anxiety control: a systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-020-03352-y
Abstract: Objective The objective of this systematic review was to determine the effectiveness of preoperative oral pregabalin for anxiety control, the most effective dosage regimen, its impact on postoperative pain, and its adverse effects. Materials and… read more here.
Keywords: pregabalin; anxiety control; anxiety; preoperative oral ... See more keywords
Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database
Sign Up to like & getrecommendations! Published in 2018 at "Drug Safety"
DOI: 10.1007/s40264-018-0695-6
Abstract: IntroductionGabapentin and pregabalin are widely prescribed to elderly people, but data on their pharmacokinetics, safety, and efficacy in this population are scarce. Neurological adverse effects are common. Atrial fibrillation (AF) associated with their use has… read more here.
Keywords: risk; gabapentin pregabalin; pregabalin; treatment ... See more keywords
The Pharmaceutical Year That Was, 2019
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Medicine"
DOI: 10.1007/s40290-019-00313-z
Abstract: There seems to have been a greater than usual invasion into pharmaceutical medicine by the legal industry this year. Some of this is commercial and financial. However, some, quite clearly, involves serious clinical hazards, where… read more here.
Keywords: medicine; pregabalin; use; year ... See more keywords
A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain
Sign Up to like & getrecommendations! Published in 2021 at "Atencion Primaria"
DOI: 10.1016/j.aprim.2021.102144
Abstract: Aim This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use. Design Systematic review. Databases Electronic databases… read more here.
Keywords: pregabalin; systematic review; sciatica; adverse events ... See more keywords
Efficacy and Safety of the Controlled-release Pregabalin Tablet (GLA5PR GLARS-NF1) and Immediate-release Pregabalin Capsule for Peripheral Neuropathic Pain: a Multicenter, Randomized, Double-blind, Parallel-group, Active-controlled, Phase III Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2020.10.009
Abstract: PURPOSE This study compared the efficacy and safety of controlled-release pregabalin (GLA5PR GLARS-NF1 tablets) with those of an immediate-release pregabalin capsule after 12 weeks' administration to patients with peripheral neuropathic pain. METHODS In this multicenter,… read more here.
Keywords: release pregabalin; pregabalin; group; scale ... See more keywords