Dronedarone (a multichannel blocker) enhances the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice
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DOI: 10.1016/j.eplepsyres.2019.04.007
Abstract: Accumulating experimental evidence indicates that some recently licensed antiarrhythmic drugs, including dronedarone (a multichannel blocker) play a crucial role in initiation of seizures in both, in vivo and in vitro studies. Some of these antiarrhythmic… read more here.
Keywords: anticonvulsant potency; dronedarone; pregabalin topiramate; mice ... See more keywords