Pregnane glycosides from Cynanchum menarandrense
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DOI: 10.1016/j.steroids.2017.06.005
Abstract: Five new pregnane-type steroidal glycosides, named menarandrosides A-E (1-2, 5-7) were isolated from the aerial parts of Cynanchum menarandrense, together with three known compounds, carumbelloside I (3), carumbelloside II (4), and pregnenolone-3-O-gentiobioside (8). Their structures… read more here.
Keywords: glycosides cynanchum; pregnane; pregnane glycosides; cynanchum menarandrense ... See more keywords
Two new pregnane alkaloids from Pachysandra terminalis Sieb. et Zucc.
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DOI: 10.1080/14786419.2020.1744143
Abstract: Two new pregnane alkaloids, (20S)-20α-cinnamoylamino-3β-dimethylamino-5-en-pregnane (1) and (20S)-20α-cinnamoylamino-3β-dimethylamino-pregnane (2), and four known alkaloids (+)-(20S)-20-(dimethylamino)-3-(3'R-isopropyl)-lactam-5α-pregn-2-en-4-one (3), axillaridine A (4), pachysamine M (5) and 20α-dimethylamino-16β-hydroxy-3β-senecioylamino-pregn-5-ene (6) were obtained from the whole herb of Pachysandra terminalis Sieb. et… read more here.
Keywords: two new; pregnane; pregnane alkaloids; pachysandra terminalis ... See more keywords
Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells
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DOI: 10.1111/epi.13703
Abstract: Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug‐resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the… read more here.
Keywords: pregnane; endothelial cells; epileptic brain; cytochrome p450 ... See more keywords
New Pregnane Glycosides from Mandevilla dardanoi and Their Anti-Inflammatory Activity
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DOI: 10.3390/molecules27185992
Abstract: Mandevilla Lindl. is an important genus of the Apocynaceae family, not only as ornamental plants but also for its medicinal uses. In Brazil, Mandevilla species are indicated to treat asthma and skin infections, their anti-inflammatory… read more here.
Keywords: pregnane glycosides; pregnane; anti inflammatory; mandevilla dardanoi ... See more keywords