PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma
Sign Up to like & getrecommendations! Published in 2018 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2018.04.024
Abstract: There is a need to identify new and more effective treatments for posttraumatic stress disorder (PTSD). Allopregnanolone and its stereoisomer pregnanolone (together termed ALLO) are metabolites of progesterone that positively and allosterically modulate GABA effects… read more here.
Keywords: plasma; allo dhp; women ptsd; ratio allo ... See more keywords
Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors
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DOI: 10.1016/j.steroids.2016.08.010
Abstract: Graphical abstract Figure. No Caption available. HighlightsSynthesis of new amide‐based inhibitors of NMDA receptors.Strong inhibitors of NMDA currents.The Caco‐2 assay was used to evaluate permeability of new compounds.Compounds with minimal or no adverse hepatic effect.Amide‐based… read more here.
Keywords: amide based; inhibitors nmda; biological properties; nmda receptors ... See more keywords
Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor.
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DOI: 10.1021/acs.orglett.7b03838
Abstract: A unique asymmetric total synthesis of the unnatural enantiomer of pregnanolone, as well as a study of its biological activity at the NMDA receptor, is reported. The asymmetry is introduced by a highly atom-economic organocatalytic… read more here.
Keywords: nmda receptor; ent pregnanolone; total synthesis; pregnanolone sulfate ... See more keywords
Behavioral effects of triazolam and pregnanolone combinations: reinforcing and sedative-motor effects in female rhesus monkeys
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2023.1142531
Abstract: Introduction Benzodiazepines (BZs) are prescribed as anxiolytics, but their use is limited by side effects including abuse liability and daytime drowsiness. Neuroactive steroids are compounds that, like BZs, modulate the effects of GABA at the… read more here.
Keywords: rhesus monkeys; pregnanolone combinations; female rhesus; triazolam pregnanolone ... See more keywords