Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor.
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DOI: 10.1021/acs.orglett.7b03838
Abstract: A unique asymmetric total synthesis of the unnatural enantiomer of pregnanolone, as well as a study of its biological activity at the NMDA receptor, is reported. The asymmetry is introduced by a highly atom-economic organocatalytic… read more here.
Keywords: nmda receptor; ent pregnanolone; total synthesis; pregnanolone sulfate ... See more keywords