Tetramethylpyrazine reduces the consequences of nitric oxide inhibition in pregnant rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28579
Abstract: Pre‐eclampsia (PE) is closely associated with perinatal morbidity and mortality and we want to investigate tetramethylpyrazine (TMP)'s effects on PE. Pregnant Sprague–Dawley rats were randomly divided into five groups: normal pregnant (PC), PE, PE+TMP 20 mg/kg,… read more here.
Keywords: tmp inhibited; pregnant rats; inhibition pregnant; name ... See more keywords
Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Science"
DOI: 10.1007/s11596-017-1825-6
Abstract: SummaryMyeloperoxidase (MPO) is released from activated neutrophils. The inflammation in preeclampsia was found to be associated with endothelial dysfunction. We hypothesized that cardiac and circulating MPO levels are elevated in hypertensive pregnancy. Systolic and diastolic… read more here.
Keywords: cardiac myeloperoxidase; pregnant rats; hypertensive pregnant; mpo activities ... See more keywords
Oral exposure of pregnant rats to copper nanoparticles caused nutritional imbalance and liver dysfunction in fetus.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111206
Abstract: Copper nanoparticles (Cu NPs) are increasingly used as an animal feed additive in China. In previous studies, it was determined that Cu NPs can penetrate the placental barrier, however, its toxic effects on the fetus… read more here.
Keywords: pregnant rats; exposure; rats copper; exposure pregnant ... See more keywords
Effects of time course ferrous sulphate supplementation on iron regulation in pregnant rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2016.12.007
Abstract: Objectives Our study aimed to evaluate the effects of ferrous sulphate supplementation on iron regulation and homeostasis in pregnant rats. Methods Twenty-four pregnant rats were divided into four groups; including the control (untreated) pregnant group… read more here.
Keywords: pregnant rats; sulphate supplementation; ferrous sulphate; trimester ... See more keywords
Activation of the cholinergic anti-inflammatory pathway by nicotine ameliorates lipopolysaccharide-induced preeclampsia-like symptoms in pregnant rats.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2016.11.003
Abstract: INTRODUCTION Preeclampsia (PE) exerts a more intense systemic inflammatory response than normal pregnancy. Recently, the role of the cholinergic anti-inflammatory pathway (CAP) in regulating inflammation has been extensively studied. The aim of this study was… read more here.
Keywords: symptoms pregnant; preeclampsia like; induced preeclampsia; pregnant rats ... See more keywords
17-Hydroxyprogesterone caproate improves hypertension and renal endothelin-1 in response to sFlt-1 induced hypertension in pregnant rats.
Sign Up to like & getrecommendations! Published in 2020 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2020.09.002
Abstract: Preeclampsia (PE) is characterized by new onset hypertension in association with elevated soluble fms-like tyrosine kinase-1 (sFlt-1) and preproendothelin-1 (PPET-1) levels. Currently there is no effective treatment for PE except for early delivery of the… read more here.
Keywords: sflt; response; pregnant rats; hydroxyprogesterone caproate ... See more keywords
Prenatal and maternal study of halloysite toxicity in pregnant rats
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-20686-3
Abstract: Halloysite nanoclay (HNC) is a naturally occurring tubular aluminosilicate that has various applications in nanotechnology and drug delivery. However, its toxic effects during gestation are inadequately reported. This study assessed the maternal and fetal toxic… read more here.
Keywords: pregnant rats; toxicity; prenatal maternal; hnc ... See more keywords
The Effect of BML-111 in Preeclampsia Rat Model Induced by the Low Dose of Cadmium Chloride
Sign Up to like & getrecommendations! Published in 2019 at "AJP Reports"
DOI: 10.1055/s-0039-1693016
Abstract: Aim This article determines the optimal time and dose of cadmium chloride (CdCl 2 ) injected to pregnant rat to establish experimental preeclampsia (PE) model. In addition, the therapeutic potential of BML-111, a lipoxin A4… read more here.
Keywords: dose cadmium; pregnant rats; model; cadmium chloride ... See more keywords
High-fat diet in pregnant rats and adverse fetal outcome
Sign Up to like & getrecommendations! Published in 2019 at "Upsala Journal of Medical Sciences"
DOI: 10.1080/03009734.2019.1604588
Abstract: Abstract Background: Although pregestational obesity has been associated with increased risk of adverse fetal outcome, the mechanisms behind are not known. We aimed to investigate the influence of the maternal metabolic state on fetal outcome… read more here.
Keywords: hfd; fetal outcome; adverse fetal; pregnant rats ... See more keywords
H2S donor GYY4137 mitigates sFlt-1-induced hypertension and vascular dysfunction in pregnant rats
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DOI: 10.1093/biolre/ioae103
Abstract: Abstract Gestational hypertension, often associated with elevated soluble Fms-related receptor tyrosine kinase 1 (sFlt-1), poses significant risks to both maternal and fetal health. Hydrogen sulfide (H2S), a gasotransmitter, has demonstrated blood pressure-lowering effects in hypertensive… read more here.
Keywords: pregnant rats; h2s; gyy4137; sflt induced ... See more keywords
Decreased insulin secretion in pregnant rats fed a low protein diet†
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1093/biolre/iox100
Abstract: ABSTRACT Low protein (LP) diet during pregnancy leads to reduced plasma insulin levels in rodents, but the underlying mechanisms remain unclear. Glucose is the primary insulin secretagogue, and enhanced glucose-stimulated insulin secretion (GSIS) in beta… read more here.
Keywords: insulin; insulin secretion; pregnant rats; plasma insulin ... See more keywords